3r91: Difference between revisions

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[[Image:3r91.png|left|200px]]
[[Image:3r91.png|left|200px]]


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{{STRUCTURE_3r91|  PDB=3r91  |  SCENE=  }}  
{{STRUCTURE_3r91|  PDB=3r91  |  SCENE=  }}  


===Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.===
===Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.===


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{{ABSTRACT_PUBMED_21515049}}
{{ABSTRACT_PUBMED_21515049}}


==About this Structure==
==About this Structure==
[[3r91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R91 OCA].  
[[3r91]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R91 OCA].  
 
==See Also==
*[[Heat Shock Proteins|Heat Shock Proteins]]


==Reference==
==Reference==
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[[Category: Vogan, E.]]
[[Category: Vogan, E.]]
[[Category: Zapf, C W.]]
[[Category: Zapf, C W.]]
[[Category: Atp binding domain]]
[[Category: Atp-binding]]
[[Category: Chaperone]]
[[Category: Chaperone-chaperone inhibitor complex]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Stress response]]

Revision as of 10:56, 26 July 2012

File:3r91.png

Template:STRUCTURE 3r91

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.

Template:ABSTRACT PUBMED 21515049

About this Structure

3r91 is a 1 chain structure of Heat Shock Proteins with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Zapf CW, Bloom JD, McBean JL, Dushin RG, Nittoli T, Otteng M, Ingalls C, Golas JM, Liu H, Lucas J, Boschelli F, Hu Y, Vogan E, Levin JI. Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity. Bioorg Med Chem Lett. 2011 Apr 5. PMID:21515049 doi:10.1016/j.bmcl.2011.03.112

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