3rom: Difference between revisions
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{{STRUCTURE_3rom| PDB=3rom | SCENE= }} | |||
===Crystal structure of human CD38 in complex with compound CZ-48=== | |||
{{ABSTRACT_PUBMED_22142305}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | |||
==About this Structure== | |||
[[3rom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROM OCA]. | |||
==See Also== | |||
*[[Cluster of Differentiation 38|Cluster of Differentiation 38]] | |||
==Reference== | |||
<ref group="xtra">PMID:022142305</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Hao, Q.]] | |||
[[Category: Lee, H C.]] | |||
[[Category: Zhang, H.]] | |||
[[Category: Adp-ribosyl cyclase]] | |||
[[Category: Calcium signaling]] | |||
[[Category: Cd38]] | |||
[[Category: Covalent intermediate]] | |||
[[Category: Cyclic adp-ribose]] | |||
[[Category: Cz-48]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Inhibitory compound]] | |||
[[Category: X-crystallography]] | |||
Revision as of 08:06, 16 May 2013
Crystal structure of human CD38 in complex with compound CZ-48
Template:ABSTRACT PUBMED 22142305
Function
[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
About this Structure
3rom is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Kwong AK, Chen Z, Zhang H, Leung FP, Lam CM, Ting KY, Zhang L, Hao Q, Zhang LH, Lee HC. Catalysis-Based Inhibitors of the Calcium Signaling Function of CD38. Biochemistry. 2011 Dec 14. PMID:22142305 doi:10.1021/bi201509f
