2xns: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
m Protected "2xns" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2xns.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_2xns", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_2xns|  PDB=2xns  |  SCENE=  }}  
{{STRUCTURE_2xns|  PDB=2xns  |  SCENE=  }}  
===CRYSTAL STRUCTURE OF HUMAN G ALPHA I1 BOUND TO A DESIGNED HELICAL PEPTIDE DERIVED FROM THE GOLOCO MOTIF OF RGS14===
===CRYSTAL STRUCTURE OF HUMAN G ALPHA I1 BOUND TO A DESIGNED HELICAL PEPTIDE DERIVED FROM THE GOLOCO MOTIF OF RGS14===
{{ABSTRACT_PUBMED_21388199}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>  [[http://www.uniprot.org/uniprot/RGS14_HUMAN RGS14_HUMAN]] Acts as a regulator of G protein signaling (RGS). Modulates G protein alpha subunits nucleotide exchange and hydrolysis activities by functioning either as a GTPase-activating protein (GAP), thereby driving G protein alpha subunits into their inactive GDP-bound form, or as a GDP-dissociation inhibitor (GDI). Confers GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not G(o) alpha subunit GNAO1 and G(i) alpha subunit GNAI2. Confers GAP activity on G(o) alpha subunit GNAI0 and G(i) alpha subunits GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS1 and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Probably required for the nerve growth factor (NGF)-mediated neurite outgrowth. May be involved in visual memory processing capacity and hippocampal-based learning and memory.<ref>PMID:15917656</ref> <ref>PMID:17635935</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_21388199}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21388199 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_21388199}}


==About this Structure==
==About this Structure==
Line 22: Line 10:


==Reference==
==Reference==
<ref group="xtra">PMID:021388199</ref><ref group="xtra">PMID:017603074</ref><ref group="xtra">PMID:011976690</ref><references group="xtra"/>
<ref group="xtra">PMID:021388199</ref><ref group="xtra">PMID:017603074</ref><ref group="xtra">PMID:011976690</ref><references group="xtra"/><references/>
[[Category: Heterotrimeric G-protein GTPase]]
[[Category: Heterotrimeric G-protein GTPase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 31: Line 19:
[[Category: Sammond, D W.]]
[[Category: Sammond, D W.]]
[[Category: Siderovski, D P.]]
[[Category: Siderovski, D P.]]
[[Category: Adp-ribosylation]]
[[Category: Arginine finger]]
[[Category: Gtp-binding]]
[[Category: Hydrolase-peptide complex]]
[[Category: Lipoprotein]]
[[Category: Nucleotide-binding]]
[[Category: Palmitate]]
[[Category: Protein-protein interface design]]
[[Category: Signaling protein]]
[[Category: Transducer]]
Retrieved from "https://proteopedia.org/2xns"