3ee1: Difference between revisions

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~~[[Image:3ee1.png|left|200px]]~~

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===Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri===

==Function==

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[[http://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_18787201}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 18787201~~ is the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_18787201}}~~

==About this Structure==

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==Reference==

[[Category: Shigella flexneri]]

[[Category: Davis, J S.]]

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-[[Image:3ee1.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3ee1", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3ee1|  PDB=3ee1  |  SCENE=  }}
 ===Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri===
+{{ABSTRACT_PUBMED_18787201}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/VIRA_SHIFL VIRA_SHIFL]] Alpha-tubulin-specific protease that is required for entry into epithelial cells and for subsequent intra- and intercellular spreading. Contributes to bacterial entry into epithelial cells by inducing microtubule (MT) destabilization and the formation of membrane ruffles. The membrane ruffling evoked by VirA results from the activation of host rac1, which is associated with the destruction of MT networks. Creates a tunnel inside the host cell cytoplasm by breaking down the microtubule infrastructure. This facilitates the bacterium's movement through the cytoplasm and also helps other bacteria move faster during the invasion of the eukaryotic cell. Is absolutely required for virulence.<ref>PMID:7494473</ref> <ref>PMID:12065406</ref> <ref>PMID:17095701</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_18787201}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 18787201 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_18787201}}
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:018787201</ref><references group="xtra"/>
+<ref group="xtra">PMID:018787201</ref><references group="xtra"/><references/>
 [[Category: Shigella flexneri]]
 [[Category: Davis, J S.]]