Potassium Channel: Difference between revisions
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This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University. | This article was developed based on lectures given in Chemistry 543 by Prof. Clarence E. Schutt at Princeton University. | ||
== | == Structures of Potassium Channels== | ||
''Update | ''Update December 2011'' | ||
Potassium channels (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''. | Potassium channels (KCh) are subdivided into voltage-gated KCh and calcium-dependent KCh. The latter are subdivided into high- (BK, LKCa), intermediate- and small-conductance KCh (human SK1, rat SK2, SKCa). The T1 domain is a highly conserved N-terminal domain which is responsible for driving the tetramerization of the KCh α subunit. The inward rectifier KCh (IRK) passes current more easily in the inward direction. MthK is a calcium-dependent KCh from ''Methanobacterium thermoautrophicum''. | ||
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[[1kn7]] - rKCh Kv1.4 N-terminal (mutant) - NMR<br /> | [[1kn7]] - rKCh Kv1.4 N-terminal (mutant) - NMR<br /> | ||
[[1nn7]] - rKCh Kv4.2 N-terminal T1 domain<br /> | [[1nn7]] - rKCh Kv4.2 N-terminal T1 domain<br /> | ||
[[3eau]] - rKCh | [[3eau]] - rKCh β-2 +cortisone<br /> | ||
[[3eb3]], [[3eb4]] - rKCh | [[3eb3]], [[3eb4]] - rKCh β-2 (mutant) + cortisone<br /> | ||
[[1a68]], [[1eod]], [[1eoe]], [[1eof]], [[3kvt]] - AcKCh Kv1.1 T1 domain (mutant) - ''Aplysia californica''<br /> | [[1a68]], [[1eod]], [[1eoe]], [[1eof]], [[3kvt]] - AcKCh Kv1.1 T1 domain (mutant) - ''Aplysia californica''<br /> | ||
[[1t1d]] - AcKCh Kv1.1 T1 domain<br /> | [[1t1d]] - AcKCh Kv1.1 T1 domain<br /> | ||
[[1b4g]] - hKCh inactivation domain - human - NMR<br /> | [[1b4g]], [[1b4i]] - hKCh inactivation domain - human - NMR<br /> | ||
[[1byw]] - hKCh ERG N-terminal (mutant)<br /> | [[1byw]] - hKCh ERG N-terminal (mutant)<br /> | ||
[[1ujl]] - hKCh ERG1 extracellular linker - NMR<br /> | [[1ujl]] - hKCh ERG1 extracellular linker - NMR<br /> | ||
[[2l1m]], [[2l4r]] - hKCh HERG - NMR<br /> | [[2l1m]], [[2l4r]], [[2l0w]] - hKCh HERG - NMR<br /> | ||
[[1s1g]] - hKCh Kv4.3 T1 domain<br /> | [[1s1g]] - hKCh Kv4.3 T1 domain<br /> | ||
[[2ovc]] - hKCh Kv7.4 T1 domain<br /> | [[2ovc]] - hKCh Kv7.4 T1 domain<br /> | ||
[[3bj4]] - hKCh Kv7.1 C-termianl<br /> | [[3bj4]] - hKCh Kv7.1 C-termianl<br /> | ||
[[3hfc]], [[3hfe]] - hKCh Kv7.1 (mutant) <br /> | [[3hfc]], [[3hfe]] - hKCh Kv7.1 (mutant) <br /> | ||
[[ | [[1zsx]] - hKCh β-2<br /> | ||
[[1ztn]] – hKCH RAW3 inactivation gate – NMR<br /> | |||
[[1zto]] - hKCH RCK4 inactivation gate – NMR<br /> | |||
[[3co2]], [[1vp6]] - MlotiK1 cyclic nucleotide binding domain - ''Mesorhizobium loti''<br /> | [[3co2]], [[1vp6]] - MlotiK1 cyclic nucleotide binding domain - ''Mesorhizobium loti''<br /> | ||
[[1ho2]], [[1ho7]] - KCh L45 segment - ''Drosophila melanogaster'' - NMR<br /> | [[1ho2]], [[1ho7]] - KCh L45 segment - ''Drosophila melanogaster'' - NMR<br /> | ||
[[2kyh]] - AeKCh voltage ensing domain - ''Aeropyrum pernix'' - NMR<br /> | [[2kyh]] - AeKCh voltage ensing domain - ''Aeropyrum pernix'' - NMR<br /> | ||
[[2wll]] - KCh KIRBAC1.1 - ''Burkholderia pseudomalie'' | [[2wll]] - KCh KIRBAC1.1 - ''Burkholderia pseudomalie''<br /> | ||
[[1bei]] - KCh Kv1.3 – ''Stichodactyla helianthus'' | |||
===Potassium channel complex with protein=== | ===Potassium channel complex with protein=== | ||
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[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br /> | [[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br /> | ||
[[2xky]] - mIRK 2 cytoplasmic domain - EM<br /> | |||
[[2gix]] - mIRK 2 cytoplasmic domain (mutant)<br /> | [[2gix]] - mIRK 2 cytoplasmic domain (mutant)<br /> | ||
[[2e4f]] - mIRK 2 fragment<br /> | [[2e4f]] - mIRK 2 fragment<br /> | ||
[[1n9p]], [[1u4e]] - mIRK 1 cytoplasmic domain<br /> | [[1n9p]], [[1u4e]] - mIRK 1 cytoplasmic domain<br /> | ||
[[3k6n]] - mIRK 1 cytoplasmic domain (mutant)<br /> | [[3k6n]] - mIRK 1 cytoplasmic domain (mutant)<br /> | ||
[[3at8]], [[3at9]], [[3ata]], [[3atb]], [[3atd]], [[3ate]], [[3atf]], [[3auw]], [[3syo]] - mIRK 3.2<br /> | |||
[[3syc]], [[3syp]] - mIRK 3.2 (mutant) <br /> | |||
[[3sya]] - mIRK 3.2 + PIP2<br /> | |||
[[3syq]] - mIRK 3.2 (mutant) + PIP2<br /> | |||
[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]] - MmIRK KIRBAC3.1<br /> | [[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]] - MmIRK KIRBAC3.1<br /> | ||
[[1p7b]] - BpIRK C-terminal | [[1p7b]] - BpIRK C-terminal<br /> | ||
[[3spc]] – cIRK 2.2 + DGPP – chicken<br /> | |||
[[3spg]], [[3sph]] – cIRK 2.2 (mutant) + PIP2<br /> | |||
[[3spi]] – cIRK 2.2 + PIP2<br /> | |||
[[3spj]] – cIRK 2.2 (mutant) | |||
===MthK=== | ===MthK=== | ||
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[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]] - MthK RCK domain<br /> | [[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]] - MthK RCK domain<br /> | ||
[[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br /> | [[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br /> | ||
[[2aef]], [[3kxd]] - MthK RCK domain + Ca | [[2aef]], [[3kxd]] - MthK RCK domain + Ca<br /> | ||
[[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca | |||
===BK channel=== | ===BK channel=== | ||
