Cation-pi interactions: Difference between revisions
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In 1998, Zhong ''et al.'' (with Dougherty)<ref name="zhong">PMID: 9770444</ref> provided evidence that the [http://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor cation in acetylcholine] engages in a cation-pi interaction with Trp149 in the receptor, accounting for | In 1998, Zhong ''et al.'' (with Dougherty)<ref name="zhong">PMID: 9770444</ref> provided evidence that the [http://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor cation in acetylcholine] engages in a cation-pi interaction with Trp149 in the receptor, making an important contribution to the binding affinity. In 2002, Beene ''et al.'' (with Dougherty)<ref name="XD" /> provided evidence that no such cation-pi interaction is involved when nicotine binds to the muscle-type receptor, thus accounting in part for the lower affinity. | ||
===Examples from Gallivan and Dougherty<ref name='GD' />=== | ===Examples from Gallivan and Dougherty<ref name='GD' />=== | ||
