2fgo: Difference between revisions

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==Overview==

The structure of the 2[4Fe-4S] ferredoxin (PaFd) from Pseudomonas, aeruginosa, which belongs to the Allochromatium vinosum (Alvin) subfamily, has been determined by X-ray crystallography at 1.32-A resolution, which, is the highest up to now for a member of this subfamily of Fds. The main, structural features of PaFd are similar to those of AlvinFd. However, the, significantly higher resolution of the PaFd structure makes possible a, reliable comparison with available high-resolution structures of, [4Fe-4S]-containing Fds, in an effort to rationalize the unusual, electrochemical properties of Alvin-like Fds. Three major factors, contributing to the reduction potential values of [4Fe-4S]2+/+ clusters of, Fds, namely, the surface accessibility of the clusters, the N-H...S, hydrogen-bonding network, and the volume of the cavities hosting the, clusters, are extensively discussed. The volume of the cavities is, introduced in the present work for the first time, and can in part explain, the very negative potential of cluster I of Alvin-like Fds.

The structure of the 2[4Fe-4S] ferredoxin (PaFd) from Pseudomonas aeruginosa, which belongs to the Allochromatium vinosum (Alvin) subfamily, has been determined by X-ray crystallography at 1.32-A resolution, which is the highest up to now for a member of this subfamily of Fds. The main structural features of PaFd are similar to those of AlvinFd. However, the significantly higher resolution of the PaFd structure makes possible a reliable comparison with available high-resolution structures of [4Fe-4S]-containing Fds, in an effort to rationalize the unusual electrochemical properties of Alvin-like Fds. Three major factors contributing to the reduction potential values of [4Fe-4S]2+/+ clusters of Fds, namely, the surface accessibility of the clusters, the N-H...S hydrogen-bonding network, and the volume of the cavities hosting the clusters, are extensively discussed. The volume of the cavities is introduced in the present work for the first time, and can in part explain the very negative potential of cluster I of Alvin-like Fds.

==About this Structure==

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[[Category: Single protein]]

[[Category: Giastas, P.]]

[[Category: Mavridis, I.M.]]

[[Category: Mavridis, I M.]]

[[Category: Pinotsis, N.]]

[[Category: SF4]]

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[[Category: reduction potential]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The structure of the 2[4Fe-4S] ferredoxin (PaFd) from Pseudomonas, aeruginosa, which belongs to the Allochromatium vinosum (Alvin) subfamily, has been determined by X-ray crystallography at 1.32-A resolution, which, is the highest up to now for a member of this subfamily of Fds. The main, structural features of PaFd are similar to those of AlvinFd. However, the, significantly higher resolution of the PaFd structure makes possible a, reliable comparison with available high-resolution structures of, [4Fe-4S]-containing Fds, in an effort to rationalize the unusual, electrochemical properties of Alvin-like Fds. Three major factors, contributing to the reduction potential values of [4Fe-4S]2+/+ clusters of, Fds, namely, the surface accessibility of the clusters, the N-H...S, hydrogen-bonding network, and the volume of the cavities hosting the, clusters, are extensively discussed. The volume of the cavities is, introduced in the present work for the first time, and can in part explain, the very negative potential of cluster I of Alvin-like Fds.
+The structure of the 2[4Fe-4S] ferredoxin (PaFd) from Pseudomonas aeruginosa, which belongs to the Allochromatium vinosum (Alvin) subfamily, has been determined by X-ray crystallography at 1.32-A resolution, which is the highest up to now for a member of this subfamily of Fds. The main structural features of PaFd are similar to those of AlvinFd. However, the significantly higher resolution of the PaFd structure makes possible a reliable comparison with available high-resolution structures of [4Fe-4S]-containing Fds, in an effort to rationalize the unusual electrochemical properties of Alvin-like Fds. Three major factors contributing to the reduction potential values of [4Fe-4S]2+/+ clusters of Fds, namely, the surface accessibility of the clusters, the N-H...S hydrogen-bonding network, and the volume of the cavities hosting the clusters, are extensively discussed. The volume of the cavities is introduced in the present work for the first time, and can in part explain the very negative potential of cluster I of Alvin-like Fds.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Giastas, P.]]
-[[Category: Mavridis, I.M.]]
+[[Category: Mavridis, I M.]]
 [[Category: Pinotsis, N.]]
 [[Category: SF4]]
@@ Line 24: / Line 24: @@
 [[Category: reduction potential]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:36:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:21:15 2008''