2le4: Difference between revisions

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~~'''Unreleased~~ structure~~'''~~

===Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2===

~~The~~ entry ~~2le4~~ is ~~ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/SOX2_HUMAN SOX2_HUMAN]] Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:[http://omim.org/entry/206900 206900]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.<ref>PMID:12612584</ref>

~~Authors~~: ~~Sahu, S~~.C., ~~Markley~~, J.L.~~, Tonelli, M~~.~~, Bahrami, A~~.~~, Eghbalnia, H.R., Center for Eukaryotic Structural Genomics~~ (~~CESG~~)

==Function==

[[http://www.uniprot.org/uniprot/SOX2_HUMAN SOX2_HUMAN]] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:18035408</ref>

~~Description~~: ~~Solution~~ structure ~~of the HMG box DNA-binding domain of human stem cell transcription factor Sox2~~

==About this Structure==

[[2le4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE4 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Bahrami, A.]]

[[Category: CESG, Center for Eukaryotic Structural Genomics.]]

[[Category: Eghbalnia, H R.]]

[[Category: Markley, J L.]]

[[Category: Sahu, S C.]]

[[Category: Tonelli, M.]]

[[Category: Center for eukaryotic structural genomic]]

[[Category: Cesg]]

[[Category: Protein structure initiative]]

[[Category: Psi]]

[[Category: Structural genomic]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2le4|  PDB=2le4  |  SCENE=  }}
+===Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2===
-The entry 2le4 is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/SOX2_HUMAN SOX2_HUMAN]] Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:[http://omim.org/entry/206900 206900]]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.<ref>PMID:12612584</ref>
-Authors: Sahu, S.C., Markley, J.L., Tonelli, M., Bahrami, A., Eghbalnia, H.R., Center for Eukaryotic Structural Genomics (CESG)
+==Function==
+[[http://www.uniprot.org/uniprot/SOX2_HUMAN SOX2_HUMAN]] Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).<ref>PMID:18035408</ref>
-Description: Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor Sox2
+==About this Structure==
+[[2le4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE4 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Bahrami, A.]]
+[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+[[Category: Eghbalnia, H R.]]
+[[Category: Markley, J L.]]
+[[Category: Sahu, S C.]]
+[[Category: Tonelli, M.]]
+[[Category: Center for eukaryotic structural genomic]]
+[[Category: Cesg]]
+[[Category: Protein structure initiative]]
+[[Category: Psi]]
+[[Category: Structural genomic]]
+[[Category: Transcription]]