DOPA decarboxylase: Difference between revisions
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==Function== | ==Function== | ||
===The Active Site=== | ===The Active Site=== | ||
The active site of DOPA decarboxylase is located in a cleft at the <scene name='DOPA_decarboxylase/Dimer_interface/2'>interface</scene> between the two subunits of the dimer, like all PLP-dependent enzymes of the aspartate aminotransferase family. Since it is at the interface, residues from both domains and both subunits are involved in cofactor binding, although the active site is composed of residues mainly from one monomer. The <scene name='DOPA_decarboxylase/Active_site/1'>active site</scene> is composed of several key residues. <scene name='DOPA_decarboxylase/Lysine2/1'>Lys303</scene> serves to bind PLP via a [http://en.wikipedia.org/wiki/Schiff_base Schiff base] linkage in the absence on substrate. | The active site of DOPA decarboxylase is located in a cleft at the <scene name='DOPA_decarboxylase/Dimer_interface/2'>interface</scene> between the two subunits of the dimer, like all PLP-dependent enzymes of the aspartate aminotransferase family. Since it is at the interface, residues from both domains and both subunits are involved in cofactor binding, although the active site is composed of residues mainly from one monomer. The <scene name='DOPA_decarboxylase/Active_site/1'>active site</scene> is composed of several key residues. <scene name='DOPA_decarboxylase/Lysine2/1'>Lys303</scene> serves to bind PLP via a [http://en.wikipedia.org/wiki/Schiff_base Schiff base] linkage in the absence on substrate. | ||
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