2yhn: Difference between revisions

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~~[[Image:2yhn.jpg|left|200px]]~~

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~~The line below this paragraph, containing "STRUCTURE_2yhn", creates the "Structure Box" on the page.~~

~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~

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===THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENT DEGRADATION OF THE LDL RECEPTOR===

==Function==

~~<!--~~

[[http://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>

~~The line below this paragraph, {{ABSTRACT_PUBMED_21685362}}, adds the Publication Abstract to the page~~

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 21685362 is~~ the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_21685362}}~~

==About this Structure==

[[2yhn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YHN OCA].

==See Also==

*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]

==Reference==

[[Category: Homo sapiens]]

[[Category: Fairall, L.]]

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@@ Line 1: / Line 1: @@
-[[Image:2yhn.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_2yhn", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_2yhn|  PDB=2yhn  |  SCENE=  }}
 ===THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENT DEGRADATION OF THE LDL RECEPTOR===
+{{ABSTRACT_PUBMED_21685362}}
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_21685362}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 21685362 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21685362}}
 ==About this Structure==
 [[2yhn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YHN OCA].
+==See Also==
+*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
 ==Reference==
-<ref group="xtra">PMID:021685362</ref><references group="xtra"/>
+<ref group="xtra">PMID:021685362</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Fairall, L.]]