Group:MUZIC:MLP: Difference between revisions
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== Structures == | == Structures == | ||
LIM domains have been intensively characterized using NMR. The | [[LIM]] domains have been intensively characterized using NMR. The two [[LIM]] domains of CSRP3 have been also determined by NMR ([http://www.pdb.org/pdb/explore/explore.do?structureId=2O10 | LIM1: 2O10 ] and [http://www.pdb.org/pdb/explore/explore.do?structureId=2O13 | LIM2: 2O13 ]) | ||
== Function and Interactions == | == Function and Interactions == | ||
All three CRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. | All three CRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. CSRP3 is localized in Z and M-lines in striated muscles. | ||
The interactions of MLP with α-actinin, telethonin<ref>PMID: 12507422</ref>, βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2) have been suggested in the literature, underlying the essential role of MLP as a scaffold protein in the sarcomere. During myogenesis MLP has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin. | The interactions of MLP with α-actinin, telethonin<ref>PMID: 12507422</ref>, βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2) have been suggested in the literature, underlying the essential role of MLP as a scaffold protein in the sarcomere. During myogenesis MLP has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin. | ||
