2hai: Difference between revisions
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New page: left|200px<br /><applet load="2hai" size="350" color="white" frame="true" align="right" spinBox="true" caption="2hai, resolution 1.58Å" /> '''Crystal structure of... |
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==Overview== | ==Overview== | ||
A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been | A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure-activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Li, H.]] | [[Category: Li, H.]] | ||
[[Category: Love, R | [[Category: Love, R L.]] | ||
[[Category: PFI]] | [[Category: PFI]] | ||
[[Category: hcv rna polymerase]] | [[Category: hcv rna polymerase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:39:51 2008'' | ||
