2i39: Difference between revisions

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==Overview==

Poxviruses encode immuno-modulatory proteins capable of subverting host, defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic, regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks, detectable Bcl-2 homology (BH) motifs at the sequence level, we show that, N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2, family proteins in vitro, consistent with a role for N1L in modulating, host antiviral defenses.

Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.

==About this Structure==

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[[Category: Single protein]]

[[Category: Vaccinia virus]]

[[Category: Aleshin, A.E.]]

[[Category: Aleshin, A E.]]

[[Category: Aoyagi, M.]]

[[Category: Liddington, R.C.]]

[[Category: Liddington, R C.]]

[[Category: Stec, B.]]

[[Category: MPD]]

[[Category: all alpha]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Poxviruses encode immuno-modulatory proteins capable of subverting host, defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic, regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks, detectable Bcl-2 homology (BH) motifs at the sequence level, we show that, N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2, family proteins in vitro, consistent with a role for N1L in modulating, host antiviral defenses.
+Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Vaccinia virus]]
-[[Category: Aleshin, A.E.]]
+[[Category: Aleshin, A E.]]
 [[Category: Aoyagi, M.]]
-[[Category: Liddington, R.C.]]
+[[Category: Liddington, R C.]]
 [[Category: Stec, B.]]
 [[Category: MPD]]
 [[Category: all alpha]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:34:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:48:37 2008''