2ibl: Difference between revisions

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==Overview==

Hantaviruses can cause hemorrhagic fever with a renal syndrome and, hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid, protein of hantaviruses encapsidates viral genomic RNA and associates with, transcription and replication complexes. Both the amino and carboxy, termini of the nucleocapsid protein had been predicted to form trimers, prior to the formation of the ribonucleoprotein. Crystal structures of, amino-terminal fragments of the nucleocapsid protein showed the formation, of intramolecular antiparallel coiled coils, but not intermolecular, trimers. Thus, the amino-terminal part of the nucleocapsid protein is, probably insufficient to initiate the trimerization of the full-length, molecule.

Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule.

==About this Structure==

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[[Category: Single protein]]

[[Category: Unidentified phage]]

[[Category: Boudko, S.P.]]

[[Category: Boudko, S P.]]

[[Category: Rossmann, M.G.]]

[[Category: Rossmann, M G.]]

[[Category: bacteriophage t4]]

[[Category: foldon]]

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[[Category: trimerization]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:50:56 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Hantaviruses can cause hemorrhagic fever with a renal syndrome and, hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid, protein of hantaviruses encapsidates viral genomic RNA and associates with, transcription and replication complexes. Both the amino and carboxy, termini of the nucleocapsid protein had been predicted to form trimers, prior to the formation of the ribonucleoprotein. Crystal structures of, amino-terminal fragments of the nucleocapsid protein showed the formation, of intramolecular antiparallel coiled coils, but not intermolecular, trimers. Thus, the amino-terminal part of the nucleocapsid protein is, probably insufficient to initiate the trimerization of the full-length, molecule.
+Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Unidentified phage]]
-[[Category: Boudko, S.P.]]
+[[Category: Boudko, S P.]]
-[[Category: Rossmann, M.G.]]
+[[Category: Rossmann, M G.]]
 [[Category: bacteriophage t4]]
 [[Category: foldon]]
@@ Line 21: / Line 21: @@
 [[Category: trimerization]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:38:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:50:56 2008''