Sandbox 121: Difference between revisions
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<applet load='3P0G' size='300' frame='true' align='right' scene='Sandbox_121/B2ar_struc/ | <applet load='3P0G' size='300' frame='true' align='right' scene='Sandbox_121/B2ar_struc/12' caption='B₂AR Active'/> | ||
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B2AR is a single chain that crosses the lipid membrane 7 times from the extracellular to cytoplasmic surface. | B2AR is a single chain that crosses the lipid membrane 7 times from the extracellular to cytoplasmic surface. | ||
There are 3 extracellular loops and 3 intracellular loops. The <scene name='Sandbox_121/B2ar_struc/9'>binding pocket</scene> is located to the center of the extracellular surface. | There are 3 extracellular loops and 3 intracellular loops. The <scene name='Sandbox_121/B2ar_struc/9'>binding pocket</scene> is located to the center of the extracellular surface. | ||
When B2AR is activated, the G-protein disassociates. A surrogate nanobody, <scene name='Sandbox_121/B2ar_struc/13'>Nb80</scene>, that is a camelid antibody produced to mimic the G-protein needed for an active state of the B2AR. | |||
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