Helicase: Difference between revisions
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{{STRUCTURE_3fht| PDB=3fht | SIZE= | {{STRUCTURE_3fht| PDB=3fht | SIZE=400| SCENE= |right| CAPTION=Human dead box ATP-dependent RNA helicase DDX19B complex with RNA, glycerin, phosphphoaminophosphonic adenylate and Mg+2, [[3fht]] }} | ||
'''Helicase''' (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal | '''Helicase''' (Hel) is a motor protein which separates nucleic acid strands like DNA double helix or self-annealed RNA. They use ATP hydrolysis for energy. Hel falls into 5 superfamilies (SF1-SF5). Some Hel contain a Helicase and RNase D C terminal | ||
Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. | Domain (HRDC). The α-thalassemia and mental retardation X-linked syndrome helicase (ATRX ), contains an ATRX-Dnmt3-Dnmt3L (ADD) domain in which many disease-related mutations are found. For details of PcrA helicase see [[Molecular Playground/PcrA Helicase]]. | ||
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