2o8l: Difference between revisions

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==Overview==

V8 protease, an extracellular protease of Staphylococcus aureus, is, related to the pancreatic serine proteases. The enzyme cleaves peptide, bonds exclusively on the carbonyl side of aspartate and glutamate, residues. Unlike the pancreatic serine proteases, V8 protease possesses no, disulfide bridges. This is a major evolutionary difference, as all, pancreatic proteases have at least two disulfide bridges. The structure of, V8 protease shows structural similarity with several other serine, proteases, specifically the epidermolytic toxins A and B from S. aureus, and trypsin, in which the conformation of the active site is almost, identical. V8 protease is also unique in that the positively charged, N-terminus is involved in determining the substrate-specificity of the, enzyme.

V8 protease, an extracellular protease of Staphylococcus aureus, is related to the pancreatic serine proteases. The enzyme cleaves peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues. Unlike the pancreatic serine proteases, V8 protease possesses no disulfide bridges. This is a major evolutionary difference, as all pancreatic proteases have at least two disulfide bridges. The structure of V8 protease shows structural similarity with several other serine proteases, specifically the epidermolytic toxins A and B from S. aureus and trypsin, in which the conformation of the active site is almost identical. V8 protease is also unique in that the positively charged N-terminus is involved in determining the substrate-specificity of the enzyme.

==About this Structure==

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[[Category: Single protein]]

[[Category: Staphylococcus aureus]]

[[Category: Delbaere, L.T.J.]]

[[Category: Delbaere, L T.J.]]

[[Category: Leduc, Y.]]

[[Category: Prasad, L.]]

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[[Category: serine protease; enzyme]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:15:40 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-V8 protease, an extracellular protease of Staphylococcus aureus, is, related to the pancreatic serine proteases. The enzyme cleaves peptide, bonds exclusively on the carbonyl side of aspartate and glutamate, residues. Unlike the pancreatic serine proteases, V8 protease possesses no, disulfide bridges. This is a major evolutionary difference, as all, pancreatic proteases have at least two disulfide bridges. The structure of, V8 protease shows structural similarity with several other serine, proteases, specifically the epidermolytic toxins A and B from S. aureus, and trypsin, in which the conformation of the active site is almost, identical. V8 protease is also unique in that the positively charged, N-terminus is involved in determining the substrate-specificity of the, enzyme.
+V8 protease, an extracellular protease of Staphylococcus aureus, is related to the pancreatic serine proteases. The enzyme cleaves peptide bonds exclusively on the carbonyl side of aspartate and glutamate residues. Unlike the pancreatic serine proteases, V8 protease possesses no disulfide bridges. This is a major evolutionary difference, as all pancreatic proteases have at least two disulfide bridges. The structure of V8 protease shows structural similarity with several other serine proteases, specifically the epidermolytic toxins A and B from S. aureus and trypsin, in which the conformation of the active site is almost identical. V8 protease is also unique in that the positively charged N-terminus is involved in determining the substrate-specificity of the enzyme.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Staphylococcus aureus]]
-[[Category: Delbaere, L.T.J.]]
+[[Category: Delbaere, L T.J.]]
 [[Category: Leduc, Y.]]
 [[Category: Prasad, L.]]
@@ Line 20: / Line 20: @@
 [[Category: serine protease; enzyme]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:07:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:15:40 2008''