Quinone reductase: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol [[2f1o]] {{STRUCTURE_2f1o| PDB=2f1o | SIZE=300| SCENE=2f1o/Com_view...
 
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{{STRUCTURE_2f1o|  PDB=2f1o  | SIZE=300| SCENE=2f1o/Com_view/2 |right|CAPTION=NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol [[2f1o]] }}
{{STRUCTURE_2f1o|  PDB=2f1o  | SIZE=300| SCENE=2f1o/Com_view/2 |right|CAPTION=NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol [[2f1o]] }}


'''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome.  '''QR1''' reduces quinines to the non-toxic hydroquinone.  The '''sulfide: quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria.  '''NADPH: quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. The images at the left and at the right correspond to one representative Quinone reductase, ''i.e.'' the crystal structure of NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol ([[2f1o]]).
'''Quinone reductase type 2 (QR2)''' catalyzes the reduction of adrenochrome.  '''QR1''' reduces quinines to the non-toxic hydroquinone.  The '''sulfide-quinone reductase (SQR)''' reduces sulfide and thus provides electrons for phototropic processes in bacteria.  '''NADPH-quinone reductase (NQR)''' catalyzes the reduction of quinone to semiquinone. The images at the left and at the right correspond to one representative Quinone reductase, ''i.e.'' the crystal structure of NADH quinone oxidoreductase (NQO1) with inhibitor dicoumarol ([[2f1o]]).


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== 3D Structures of Quinone reductase ==
== 3D Structures of Quinone reductase ==


Quinone reductase type 2
===Quinone reductase type 2===
 
[[3fw1]], [[1qr2]] – hQR2 - human<br />
[[3o2n]], [[3g5m]], [[3gam]] – hQR2 + PET agent<br />
[[3ovm]], [[3owh]], [[3owx]] – hQR2 + carbamate derivative<br />
[[3ox1]], [[2qx4]], [[2qx6]], [[2qx8]], [[2qx9]], [[2qwx]] – hQR2 + acetamide derivative<br />
[[3ox2]] - hQR2 + indole derivative<br />
[[3ox3]] - hQR2 + carboxamide derivative<br />
[[3o73]] – hQR2 + indolequinone<br />
[[2qmy]] – hQR2 + adrenochrome<br />
[[2qr2]] – hQR2 + menadione<br />
[[2qmz]] – hQR2 + dopamine<br />
[[1sg0]] – hQR2 + resveratol<br />
[[2bzs]], [[1xi2]], [[1zx1]] – hQR2 + anti-cancer prodrug<br />


3fw1, 1qr2 – hQR2 - human
===Quinone reductase type 1===
3o2n, 3g5m, 3gam – hQR2 + PET agent
3ovm, 3owh, 3owx – hQR2 + carbamate derivative
3ox1, 2qx4, 2qx6, 2qx8, 2qx9, 2qwx – hQR2 + acetamide derivative
3ox2 - hQR2 + indole derivative
3ox3 - hQR2 + carboxamide derivative
3o73 – hQR2 + indolequinone
2qmy – hQR2 + adrenochrome
2qr2 – hQR2 + menadione
2qmz – hQR2 + dopamine
1sg0 – hQR2 + resveratol
2bzs, 1xi2, 1zx1 – hQR2 + anti-cancer prodrug


Quinone reductase type 1
[[3jsx]] – hQR1 + coumarine derivative<br />
[[2f1o]] – hQR1 + dicoumarol<br />
[[1kbo]], [[1kbq]] – hQR1 + indole derivative<br />


3jsx – hQR1 + coumarine derivative
===Sulfide-quinone reductase===
2f1o – hQR1 + dicoumarol
1kbo, 1kbq – hQR1 + indole derivative


Sulfide:quinone reductase
[[3hyv]] – AaSQR – ''Aquifex aeolicus''<br />
[[3hyw]] – AaSQR + decylubiquinone<br />
[[3hyx]] – AaSQR + Aurachin C<br />


3hyv – AaSQR – Aquifex aeolicus
===NADPH-quinone reductase===
3hyw – AaSQR + decylubiquinone
3hyx – AaSQR + Aurachin C


NADPH:quinone reductase
[[3ha2]] – NQR – ''Pediococcus pentosaceus''<br />
[[1dxq]], [[1d4a]] - hNQR<br />
[[1yb5]] – hNQR + NADP<br />
[[1gg5]], [[1h66]], [[1h69]], [[1qbg]] - hNQR + anti-cancer prodrug<br />
[[1dxo]] - hNQR + quinone derivative<br />


3ha2 – NQR – Pediococcus pentosaceus
[[Category:Topic Page]]
1dxq, 1d4a - hNQR
1yb5 – hNQR + NADP
1gg5, 1h66, 1h69, 1qbg - hNQR + anti-cancer prodrug
1dxo - hNQR + quinone derivative
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