2y8e: Difference between revisions

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[[~~Image~~:2y8e.~~png|left|200px~~]]

==CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP==

== Structural highlights ==

<table><tr><td colspan='2'>[[2y8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8E OCA]. <br>

</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>

<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>

<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8e RCSB], [http://www.ebi.ac.uk/pdbsum/2y8e PDBsum]</span></td></tr>

<table>

== Publication Abstract from PubMed ==

Rab6 is a small GTPase that belongs to the p21 Ras superfamily. It is involved in vesicle trafficking between the Golgi apparatus and endosomes/ER in eukaryotes. The GDP-bound inactive protein undergoes conformational changes when the nucleotide is exchanged to GTP, allowing Rab6 to interact with a variety of different effector proteins. To further understand how these changes affect downstream protein binding, the crystal structure of Rab6 from Drosophila melanogaster has been solved to 1.4 A resolution, the highest resolution for a Rab6 structure to date. The crystals belonged to space group C2, with unit-cell parameters a = 116.5, b = 42.71, c = 86.86 A, alpha = 90, beta = 133.12, gamma = 90 degrees . The model was refined to an R factor of 14.5% and an R(free) of 17.3%.

~~<!--~~

Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 A resolution.,Walden M, Jenkins HT, Edwards TA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt, 7):744-8. Epub 2011 Jun 23. PMID:21795785<ref>PMID:21795785</ref>

~~The line below this paragraph~~, ~~containing "STRUCTURE_2y8e"~~, ~~creates the "Structure Box" on the page~~.

~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)

~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~

~~or leave the SCENE parameter empty for the default display~~.

-->

~~{{STRUCTURE_2y8e| PDB=2y8e | SCENE= }}~~

~~===CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP===~~

From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

~~<!--~~

~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21795785}}, adds~~ the ~~Publication Abstract to the page~~

__TOC__

~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21795785 is the PubMed ID number~~.

</StructureSection>

-->

~~{{ABSTRACT_PUBMED_21795785}}~~

~~==About this Structure==~~

~~[[2y8e]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8E OCA].~~

==~~Reference~~==

<~~ref group="xtra">PMID:021795785<~~/~~ref~~><~~references group="xtra"~~/>

[[Category: Drosophila melanogaster]]

[[Category: Edwards, T A.]]

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@@ Line 1: / Line 1: @@
-[[Image:2y8e.png|left|200px]]
+==CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP==
+<StructureSection load='2y8e' size='340' side='right' caption='[[2y8e]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2y8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8E OCA]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y8e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y8e RCSB], [http://www.ebi.ac.uk/pdbsum/2y8e PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Rab6 is a small GTPase that belongs to the p21 Ras superfamily. It is involved in vesicle trafficking between the Golgi apparatus and endosomes/ER in eukaryotes. The GDP-bound inactive protein undergoes conformational changes when the nucleotide is exchanged to GTP, allowing Rab6 to interact with a variety of different effector proteins. To further understand how these changes affect downstream protein binding, the crystal structure of Rab6 from Drosophila melanogaster has been solved to 1.4 A resolution, the highest resolution for a Rab6 structure to date. The crystals belonged to space group C2, with unit-cell parameters a = 116.5, b = 42.71, c = 86.86 A, alpha = 90, beta = 133.12, gamma = 90 degrees . The model was refined to an R factor of 14.5% and an R(free) of 17.3%.
-<!--
+Structure of the Drosophila melanogaster Rab6 GTPase at 1.4 A resolution.,Walden M, Jenkins HT, Edwards TA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt, 7):744-8. Epub 2011 Jun 23. PMID:21795785<ref>PMID:21795785</ref>
-The line below this paragraph, containing "STRUCTURE_2y8e", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_2y8e|  PDB=2y8e  |  SCENE=  }}
-===CRYSTAL STRUCTURE OF D. MELANOGASTER RAB6 GTPASE BOUND TO GMPPNP===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_21795785}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 21795785 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_21795785}}
-==About this Structure==
-[[2y8e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y8E OCA].
-==Reference==
-<ref group="xtra">PMID:021795785</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
 [[Category: Edwards, T A.]]