2oxj: Difference between revisions

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New page: left|200px<br /><applet load="2oxj" size="350" color="white" frame="true" align="right" spinBox="true" caption="2oxj, resolution 2.00Å" /> '''Helix Bundle Quatern...
 
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caption="2oxj, resolution 2.00&Aring;" />
caption="2oxj, resolution 2.00&Aring;" />
'''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.'''<br />
'''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.'''<br />
==Overview==
The function of a protein generally depends on adoption of a specific, folding pattern, which in turn is determined by the side chain sequence, along the polypeptide backbone. Here we show that the sequence-encoded, structural information in peptides derived from yeast transcriptional, activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers, that adopt helix bundle quaternary structures. Crystal structures of two, hybrid alpha/beta-peptides are reported along with detailed structural, comparison to alpha-peptides of analogous side chain sequence. There is, considerable homology between alpha- and alpha/beta-peptides at the level, of helical secondary structure, with modest but significant differences in, the association geometry of helices in the quaternary structure.


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]
Helix bundle quaternary structure from alpha/beta-peptide foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Gellman, S.H.]]
[[Category: Gellman, S H.]]
[[Category: Horne, W.S.]]
[[Category: Horne, W S.]]
[[Category: Keck, J.L.]]
[[Category: Keck, J L.]]
[[Category: Price, J.L.]]
[[Category: Price, J L.]]
[[Category: ACT]]
[[Category: ACT]]
[[Category: coiled coil]]
[[Category: coiled coil]]
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[[Category: helix bundle]]
[[Category: helix bundle]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:17:23 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:41 2008''

Revision as of 16:23, 21 February 2008

File:2oxj.gif


2oxj, resolution 2.00Å

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Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-p1 with beta-residues at b and f heptad positions.

About this Structure

2OXJ is a Protein complex structure of sequences from [1] with ACT as ligand. Full crystallographic information is available from OCA.

Reference

Helix bundle quaternary structure from alpha/beta-peptide foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:17362016

Page seeded by OCA on Thu Feb 21 18:23:41 2008

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