2oxk: Difference between revisions

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caption="2oxk, resolution 2.00Å" />

'''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.'''<br />

~~==Overview==~~

The function of a protein generally depends on adoption of a specific, folding pattern, which in turn is determined by the side chain sequence, along the polypeptide backbone. Here we show that the sequence-encoded, structural information in peptides derived from yeast transcriptional, activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers, that adopt helix bundle quaternary structures. Crystal structures of two, hybrid alpha/beta-peptides are reported along with detailed structural, comparison to alpha-peptides of analogous side chain sequence. There is, considerable homology between alpha- and alpha/beta-peptides at the level, of helical secondary structure, with modest but significant differences in, the association geometry of helices in the quaternary structure.

==About this Structure==

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==Reference==

Helix ~~Bundle Quaternary Structure~~ from alpha/beta-~~Peptide Foldamers~~., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]

Helix bundle quaternary structure from alpha/beta-peptide foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]

[[Category: Protein complex]]

[[Category: Gellman, S.H.]]

[[Category: Gellman, S H.]]

[[Category: Horne, W.S.]]

[[Category: Horne, W S.]]

[[Category: Keck, J.L.]]

[[Category: Keck, J L.]]

[[Category: Price, J.L.]]

[[Category: Price, J L.]]

[[Category: FMT]]

[[Category: coiled coil]]

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[[Category: helix bundle]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:43 2008''

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@@ Line 2: / Line 2: @@
 caption="2oxk, resolution 2.00&Aring;" />
 '''Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers: GCN4-pLI with beta-residues at b and f heptad positions.'''<br />
-==Overview==
-The function of a protein generally depends on adoption of a specific, folding pattern, which in turn is determined by the side chain sequence, along the polypeptide backbone. Here we show that the sequence-encoded, structural information in peptides derived from yeast transcriptional, activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers, that adopt helix bundle quaternary structures. Crystal structures of two, hybrid alpha/beta-peptides are reported along with detailed structural, comparison to alpha-peptides of analogous side chain sequence. There is, considerable homology between alpha- and alpha/beta-peptides at the level, of helical secondary structure, with modest but significant differences in, the association geometry of helices in the quaternary structure.
 ==About this Structure==
@@ Line 10: / Line 7: @@
 ==Reference==
-Helix Bundle Quaternary Structure from alpha/beta-Peptide Foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]
+Helix bundle quaternary structure from alpha/beta-peptide foldamers., Horne WS, Price JL, Keck JL, Gellman SH, J Am Chem Soc. 2007 Apr 11;129(14):4178-80. Epub 2007 Mar 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17362016 17362016]
 [[Category: Protein complex]]
-[[Category: Gellman, S.H.]]
+[[Category: Gellman, S H.]]
-[[Category: Horne, W.S.]]
+[[Category: Horne, W S.]]
-[[Category: Keck, J.L.]]
+[[Category: Keck, J L.]]
-[[Category: Price, J.L.]]
+[[Category: Price, J L.]]
 [[Category: FMT]]
 [[Category: coiled coil]]
@@ Line 21: / Line 18: @@
 [[Category: helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:17:27 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:23:43 2008''