357d: Difference between revisions

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==Overview==

Two new RNA structures portray how non-Watson-Crick base pairs and metal, ions can produce a unique RNA shape suitable for recognition by proteins., The crystal structures of a 62 nt domain of E. coli 5S ribosomal RNA and a, duplex dodecamer encompassing an internal loop E have been determined at, 3.0 and 1.5 A, respectively. This loop E region is distorted by three, "cross-strand purine stacks" and three novel, water-mediated noncanonical, base pairs and stabilized by a four metal ion zipper. These features give, its minor groove a unique hydrogen-bonding surface and make the adjacent, major groove wide enough to permit recognition by the ribosomal protein, L25, which is expected to bind to this surface.

Two new RNA structures portray how non-Watson-Crick base pairs and metal ions can produce a unique RNA shape suitable for recognition by proteins. The crystal structures of a 62 nt domain of E. coli 5S ribosomal RNA and a duplex dodecamer encompassing an internal loop E have been determined at 3.0 and 1.5 A, respectively. This loop E region is distorted by three "cross-strand purine stacks" and three novel, water-mediated noncanonical base pairs and stabilized by a four metal ion zipper. These features give its minor groove a unique hydrogen-bonding surface and make the adjacent major groove wide enough to permit recognition by the ribosomal protein L25, which is expected to bind to this surface.

==About this Structure==

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[[Category: ]]

[[Category: Protein complex]]

[[Category: Correll, C.C.]]

[[Category: Correll, C C.]]

[[Category: Freeborn, B.]]

[[Category: Moore, P.B.]]

[[Category: Moore, P B.]]

[[Category: Steitz, T.A.]]

[[Category: Steitz, T A.]]

[[Category: HG]]

[[Category: MG]]

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[[Category: u-rna]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:16 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Two new RNA structures portray how non-Watson-Crick base pairs and metal, ions can produce a unique RNA shape suitable for recognition by proteins., The crystal structures of a 62 nt domain of E. coli 5S ribosomal RNA and a, duplex dodecamer encompassing an internal loop E have been determined at, 3.0 and 1.5 A, respectively. This loop E region is distorted by three, "cross-strand purine stacks" and three novel, water-mediated noncanonical, base pairs and stabilized by a four metal ion zipper. These features give, its minor groove a unique hydrogen-bonding surface and make the adjacent, major groove wide enough to permit recognition by the ribosomal protein, L25, which is expected to bind to this surface.
+Two new RNA structures portray how non-Watson-Crick base pairs and metal ions can produce a unique RNA shape suitable for recognition by proteins. The crystal structures of a 62 nt domain of E. coli 5S ribosomal RNA and a duplex dodecamer encompassing an internal loop E have been determined at 3.0 and 1.5 A, respectively. This loop E region is distorted by three "cross-strand purine stacks" and three novel, water-mediated noncanonical base pairs and stabilized by a four metal ion zipper. These features give its minor groove a unique hydrogen-bonding surface and make the adjacent major groove wide enough to permit recognition by the ribosomal protein L25, which is expected to bind to this surface.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: ]]
 [[Category: Protein complex]]
-[[Category: Correll, C.C.]]
+[[Category: Correll, C C.]]
 [[Category: Freeborn, B.]]
-[[Category: Moore, P.B.]]
+[[Category: Moore, P B.]]
-[[Category: Steitz, T.A.]]
+[[Category: Steitz, T A.]]
 [[Category: HG]]
 [[Category: MG]]
@@ Line 27: / Line 27: @@
 [[Category: u-rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:36:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:02:16 2008''