Response regulator: Difference between revisions
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'''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. | '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. | ||
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. | Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. Details on response regulator PleD see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]]. For details on PhoP see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]]. | ||
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== 3D Structures of response regulator == | == 3D Structures of response regulator == | ||
''Updated December 2011'' | |||
[[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br /> | [[3sft]] – TmCheB methyltransferase catalytic domain – ''Thermotoga maritima''<br /> | ||
[[1u0s]] – TmCheA + CheY<br /> | |||
[[1p2f]] – TmDrrB<br /> | [[1p2f]] – TmDrrB<br /> | ||
[[1kgs]] - TmDrrD<br /> | |||
[[3gl9]], [[3dgf]] – TmRR<br /> | [[3gl9]], [[3dgf]] – TmRR<br /> | ||
[[3snk]] – CheY-like – ''Mesorhizobium loti''<br /> | [[3snk]] – CheY-like – ''Mesorhizobium loti''<br /> | ||
[[3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br /> | [[1fc3]], [[1dz3]], [[1qmp]] – BsSpo0A - ''Bacillus subtilis''<br /> | ||
[3crn]], [[3cg4]] - CheY-like – ''Methanospirillum hungatei''<br /> | |||
[[1ixm]] – BsSpo0B<br /> | [[1ixm]] – BsSpo0B<br /> | ||
[[1nat]] – BsSPo0F<br /> | [[1nat]] – BsSPo0F<br /> | ||
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[[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br /> | [[1xhe]] – EcArcA (mutant) - ''Escherichia coli''<br /> | ||
[[1jbe]] - EcCheY<br /> | [[1jbe]] - EcCheY<br /> | ||
[[1mih]] - EcCheY (mutant)<br /> | |||
[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br /> | [[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpRR MICA receiver domain<br /> | ||
[[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br /> | [[2gwr]] – MtMtrA - ''Mycobacterium tuberculosis''<br /> | ||
[[3c3w]] – MtDosR <br /> | |||
[[2y79]] – MtDooS GAP domain (mutant)<br /> | |||
[[1ys6]] – MtPrrA<br /> | [[1ys6]] – MtPrrA<br /> | ||
[[1k66]] – ToRcpB – ''Tolypothrix''<br /> | [[1k66]] – ToRcpB – ''Tolypothrix''<br /> | ||
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[[3p01]] – RR residues 134-315 – ''Nostoc''<br /> | [[3p01]] – RR residues 134-315 – ''Nostoc''<br /> | ||
[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br /> | [[3ilh]] – RR – ''Cytophaga hutchinsonii''<br /> | ||
[[2qvg]] – RR – ''Legionella pneumophila''<br /> | [[2qvg]] – RR – ''Legionella pneumophila''<br /> | ||
[[2qr3]] – RR – ''Bacterioides fragilis''<br /> | [[2qr3]] – RR – ''Bacterioides fragilis''<br /> | ||
[[2chy]] – CheY – ''Salmonella typhimurium'' | |||
===Response regulator signal receiving domain=== | ===Response regulator signal receiving domain=== | ||
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[[2zwm]]– BsYycF <br /> | [[2zwm]]– BsYycF <br /> | ||
[[1mvo]] - BsPhoP <br /> | [[1mvo]] - BsPhoP <br /> | ||
[[2pkx]] - EcPhoP <br /> | |||
[[3gkg]], [[2i6f]] – MxFrzS <br /> | [[3gkg]], [[2i6f]] – MxFrzS <br /> | ||
[[2nt3]], [[2nt4]] - MxFrzS (mutant) <br /> | [[2nt3]], [[2nt4]] - MxFrzS (mutant) <br /> | ||
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[[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR /> | [[1umq]] – PrrA – ''Rhodobacter sphaeroides'' – NMR<BR /> | ||
[[3c57]] – MtDosR <br /> | [[3c57]] – MtDosR <br /> | ||
[[2pmu]] – MtPhoP | [[3zxo]] – MtDosS<br /> | ||
[[3zxq]] – MtDosT<br /> | |||
[[2pmu]] – MtPhoP<br /> | |||
[[1irz]] – Arr10-B – ''Arabidopsis thaliana'' - NMR | |||
===Response regulator complex=== | ===Response regulator complex=== | ||
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[[3a10]] - TmTrrA (mutant) + Mg + BeF3<br /> | [[3a10]] - TmTrrA (mutant) + Mg + BeF3<br /> | ||
[[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br /> | [[3rqi]] – RR + phosphorylated aspartic acid + citrate + Ca – ''Burkholderia pseudomallei''<br /> | ||
[[3q15]] – BsRapH + sporulation initiation phosphotransferase | [[3q15]] – BsRapH + sporulation initiation phosphotransferase <br /> | ||
[[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br /> | [[3m6m]] – RpfF residues 400-541 + RpfF protein REC domain – ''Xanthomonas campestris''<br /> | ||
[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br /> | [[1mav]], [[1mb0]], [[1mb3]] – CvDivK + metal ion<br /> | ||
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[[3dge]] – TmRR + SP cytoplasmic domain<br /> | [[3dge]] – TmRR + SP cytoplasmic domain<br /> | ||
[[3a0r]] – TmTrrA + histidine kinase ThkA<br /> | [[3a0r]] – TmTrrA + histidine kinase ThkA<br /> | ||
[[1zg1]], [[1zg5]], [[1je8]] – EcNarL DNA-binding domain + DNA | [[1zg1]], [[1zg5]], [[1je8]] – EcNarL DNA-binding domain + DNA<br /> | ||
[[1p6q]] – SmChey2 + Mg – ''Sinorhizobium meliloti'' – NMR<br /> | |||
[[1p6u]] – SmChey2 + Mg + BeF3 – NMR | |||
