Prp19: Difference between revisions
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=The Nineteen Complex= | =The Nineteen Complex= | ||
The NTC consists of at least 8 protein components and is associated with the spliceosome as U4 dissociates or immediately thereafter. Research has shown that the PRP19 associated complex is required for a reaction in which the structure of the U6 snRNP is re-arranged, involving destabilization of [http://en.wikipedia.org/wiki/LSm<i>Lsm</i>] proteins. This destabilization is thought to help facilitate interaction between the intron closest to the 5’ splice site and the Lsm binding site of U6.<ref>PMID:16540691</ref> The NTC may also function to increase specificity between the U5 snRNP and the 5' splice site. Additionally, it may play a role in the specificity of the base pairing between U5 and U6. Currently it is uncertain whether base pairing between U2 and U6 requires participation of the NTC complex.<ref>pmid:15994330</ref> | The NTC consists of at least 8 protein components and is associated with the spliceosome as U4 dissociates or immediately thereafter. Research has shown that the PRP19 associated complex is required for a reaction in which the structure of the U6 snRNP is re-arranged, involving destabilization of [http://en.wikipedia.org/wiki/LSm<i>Lsm</i>] proteins. This destabilization is thought to help facilitate interaction between the intron closest to the 5’ splice site and the Lsm binding site of U6.<ref>PMID:16540691</ref> The NTC may also function to increase specificity between the U5 snRNP and the 5' splice site. Additionally, it may play a role in the specificity of the base pairing between U5 and U6. Currently it is uncertain whether base pairing between U2 and U6 requires participation of the NTC complex.<ref>pmid:15994330</ref> | ||
==3D structures of pre-mRNA-splicing factors== | |||
[[Pre-mRNA-splicing factor]] | |||
=References= | =References= | ||
<references /> | <references /> | ||
