3iyu: Difference between revisions

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[[Image:3iyu.png|left|200px]]
==Atomic model of an infectious rotavirus particle==
<StructureSection load='3iyu' size='340' side='right' caption='[[3iyu]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3iyu]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_rotavirus_a Simian rotavirus a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IYU FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n09|3n09]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iyu RCSB], [http://www.ebi.ac.uk/pdbsum/3iyu PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Non-enveloped viruses of different types have evolved distinct mechanisms for penetrating a cellular membrane during infection. Rotavirus penetration appears to occur by a process resembling enveloped-virus fusion: membrane distortion linked to conformational changes in a viral protein. Evidence for such a mechanism comes from crystallographic analyses of fragments of VP4, the rotavirus-penetration protein, and infectivity analyses of structure-based VP4 mutants. We describe here the structure of an infectious rotavirus particle determined by electron cryomicroscopy (cryoEM) and single-particle analysis at about 4.3 A resolution. The cryoEM image reconstruction permits a nearly complete trace of the VP4 polypeptide chain, including the positions of most side chains. It shows how the two subfragments of VP4 (VP8(*) and VP5(*)) retain their association after proteolytic cleavage, reveals multiple structural roles for the beta-barrel domain of VP5(*), and specifies interactions of VP4 with other capsid proteins. The virion model allows us to integrate structural and functional information into a coherent mechanism for rotavirus entry.


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Atomic model of an infectious rotavirus particle.,Settembre EC, Chen JZ, Dormitzer PR, Grigorieff N, Harrison SC EMBO J. 2011 Jan 19;30(2):408-16. Epub 2010 Dec 14. PMID:21157433<ref>PMID:21157433</ref>
The line below this paragraph, containing "STRUCTURE_3iyu", creates the "Structure Box" on the page.
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{{STRUCTURE_3iyu|  PDB=3iyu  |  SCENE=  }}


===Atomic model of an infectious rotavirus particle===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
</div>
 
== References ==
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{{ABSTRACT_PUBMED_21157433}}
 
==About this Structure==
[[3iyu]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_rotavirus_a Simian rotavirus a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYU OCA].
 
==Reference==
<ref group="xtra">PMID:021157433</ref><references group="xtra"/>
[[Category: Simian rotavirus a]]
[[Category: Simian rotavirus a]]
[[Category: Chen, J Z.]]
[[Category: Chen, J Z.]]

Revision as of 09:51, 21 May 2014

Atomic model of an infectious rotavirus particle

3iyu, resolution 3.80Å

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