GTP-binding protein: Difference between revisions

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New page: left|200px|thumb|Crystal Structure of GTP-binding protein complex with nucleotide [[2nzj]] {{STRUCTURE_2nzj| PDB=2nzj | SIZE=300| SCENE= |right|CAPTION=GTP-binding pro...
 
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[[Image:2nzj.png|left|200px|thumb|Crystal Structure of GTP-binding protein complex with nucleotide [[2nzj]]]]
[[Image:2nzj.png|left|200px|thumb|Crystal Structure of GTP-binding protein complex with nucleotide [[2nzj]]]]
{{STRUCTURE_2nzj|  PDB=2nzj  | SIZE=300| SCENE= |right|CAPTION=GTP-binding protein complex with nucleotide [[2nzj]] }}
{{STRUCTURE_2nzj|  PDB=2nzj  | SIZE=300| SCENE= |right|CAPTION=GTP-binding protein complex with nucleotide [[2nzj]] }}
'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell.  They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. The images at the left and at the right correspond to one representative G protein, ''i.e.'' the crystal structure of human GTP-binding protein complex with nucleotide ([[2nzj]]).
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== 3D Structures of GTP-binding protein ==
===GTP-binding protein===
[[3r7w]] – yGtr1 + Gtr2 – yeast<br />
[[2dpx]] – hRad GTPase domain - human
[[3kxk]], [[3kxl]] – SsHflx (mutant) - Sulfolobus solfataricus
[[2qtf]] – SsHflx
[[1ega]] – EcERA – Escherichia coli
[[2dyk]] – TtEngA N terminal – Thermus thermophilus - Cryo EM
[[3cb4]] - EcLepA
[[2ywe]] – AaLepA
[[1sul]] – BsYsxC - Bacillus subtilis
[[2dwq]] – TtYchF
[[1udx]] – TtObg
[[1wxq]] – GBP – Pyrococcus horikoshii
[[1ni3]] – YchF – Schizosaccharomyces pombe
GTP-binding protein complex with nucleotide
2nzj – hRem1 + GDP
3cbq – hRem2 + GDP
2cjw, 2ht6, 2g3y – hGem G domain + GDP
2ohf – hOla1 + AMP-PCP
1xtq – hRheB + GDP
1xts - hRheB + GTP
1xtr - hRheB + GPPNHP
3kxi, 2qth – SsHflx + GDP
3ieu – EcERA + GDP
3iev – AaERA + RNA + Mg-GNP – Aquifex aeolicus
1x1l – TtERA + RNA – Cryo EM
2ywf – AaLepA + GMP-PNP
2ywg - AaLepA + GTP
2ywh - AaLepA + GDP
1yzn – yPt1 + GPPNHP
1ky2 – yPt7 + GPPNHP
1ky3 – yPt7 + GDP
1ek0 – yPt51 + GPPNHP
2hjg – BsEngA + GDP
1svi – BsYsxC + GDP
1svw – BsYsxC + GMPPNP
1lnz – BsObg + GTP
2dby – TtYchF + GDP
1wf3 – Tt1341 + GNP
2gao - hSar1A + GDP
2fa9 – ChSar1B (mutant) + GDP – Chinese hamster
2fmx - ChSar1B + GDP
1byu – Ran + GDP - dog
GTP-binding protein complex with protein
1ees – hCdc42 + MapK3 peptide - NMR
1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM
3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM
3cue – yPt1 + transport protein subunits
2bcg, 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor
3cpj – yPt31 + Rab GDP-dissociation inhibitor
1m2o – ySar1 + protein transport protein sec23
Ras-related GTP-binding protein
3llu – hC nucleotide-binding domain
Ras-related GTP-binding protein complex with nucleotide
2l0x – Rheb + GDP – rat
2gjs – hRad1 + GDP
2gf0 – hDiRas1 + GDP
2erx – hDiRas2 + Pi + GDP
1x3s – hRab-18 + GPPNHP
1yu9 - hRab-4A + GPPNHP
2atx – hTc10 + GPPNHP
1g16 – ySec4 + GDP
1g17 - ySec4 + GIP
Ras-related GTP-binding protein complex with protein
3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase
3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 4
3brw - hRap-1B + Rap GTPase-activating protein
1z0k – hRab-4 + rabenosyn-5
Interferon-induced GTP-binding protein
3ljb – hMx1 stalk region
Rho-related GTP-binding protein
2j1l – hRhoD
Ras-related GTP-binding protein complex with nucleotide
2cls – hRho6 + GTP
2fv8 - hRhoB + GDP
2gcn – hRhoC + GDP
2gco – hRhoC + GPPNHP
1z2c - hRhoC (mutant) + GMPPNP
2gcp – hRhoC + GSP
1m7b - hRhoE + GTP
1gwn - RhoE + GTP - mouse
1a4r - hCdc42 (mutant) + GDP
1an0 - hCdc42 + GDP
Ras-related GTP-binding protein complex with protein
2v55 – hRhoE + Rho-associated protein kinase
3q3j – hRho6 + plexin-A2 nucleotide-binding domain
2rex – hRho6 + plexin-B1
1cc0 – hRhoA + GDP-dissociation inhibitor + GDP
3a58 – yRho1 (mutant) + exocyst complex component Sec3
1gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium
1ki1 – hCdc42 + intersectin long form
1ees – hCdc42 + MapK3 peptide - NMR
1doa - hCdc42 + GDP-dissociation inhibitor
Rac-like GTP-binding protein
2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana
3bwd – AtArac6
2nty – AtArac5 + prone8
2j0v – AtArac7 (mutant)
Rab-related GTP-binding protein
2ys8 – hRabJ DNAJ domain – NMR
Flagella-associated GTP-binding protein
2px0 – BsFlhF + GMP-PNP
2px3 – BsFlhF + GTP
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