Ricin: Difference between revisions

Line 10:

==Physiology==

The mechanism deployed by Ricin to gain entry to a host cell ~~uses~~ the heterogenic properties ~~given to the toxin~~. ~~Firstly~~ the toxin arranges itself in such a way where its B chain can easily interact with the host cells receptors, and once acknowledgement happens, the B chain can ~~fascilitate~~ transport of the A chain into the cytoplasm<ref name="montfort" />. This association between the A and B chain is essential for toxicity<ref name="montfort" /> without it the Ricin would not be able to gain access to the cells organelles rendering it useless. Once the A chain gains entry into the cytosol its mechanism for attack of the [[Ribosome|ribosome]] is depurination of a single ~~endenosine~~ residue in large RNA of the [[Large Ribosomal Subunit of Haloarcula|large ribosomal subunit]]<ref name="rapak" />, which in humans is called the 28S ribosomal RNA because of its sedimentation properties during ultracentrifugation. Depurination of the ~~ribosomal RNA~~ by the ~~poison in turn~~ results in the inhibition of protein synthesis.

The mechanism deployed by Ricin to gain entry to a host cell involves the poison's heterogenic properties. First, the toxin arranges itself in such a way where its B chain can easily interact with the host cells receptors, and once acknowledgement happens, the B chain can facilitate transport of the A chain into the cytoplasm<ref name="montfort" />. This association between the A and B chain is essential for toxicity<ref name="montfort" /> without it the Ricin would not be able to gain access to the cells organelles rendering it useless. Once the A chain gains entry into the cytosol its mechanism for attack of the [[Ribosome|ribosome]] is depurination of a single adenosine residue in a highly conserved portion within the large RNA of the [[Large Ribosomal Subunit of Haloarcula|large ribosomal subunit]]<ref name="rapak" /> of eukaryotes, which in humans is called the 28S ribosomal RNA because of its sedimentation properties during ultracentrifugation. The nucleotide depurinated is located within a loop referred to as the the the <nowiki>'</nowiki>sarcin-ricin loop<nowiki>'</nowiki>, that is important for binding [[elongation factors]] during the course of [[Translation|translation]]. Depurination of the single adenosine nucleotide by the toxin results in the inhibition of protein synthesis.

==3D structures of ricin==

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 10: / Line 10: @@
 ==Physiology==
-	The mechanism deployed by Ricin to gain entry to a host cell uses the heterogenic properties given to the toxin. Firstly the toxin arranges itself in such a way where its B chain can easily interact with the host cells receptors, and once acknowledgement happens, the B chain can fascilitate transport of the A chain into the cytoplasm<ref name="montfort" />. This association between the A and B chain is essential for toxicity<ref name="montfort" /> without it the Ricin would not be able to gain access to the cells organelles rendering it useless. Once the A chain gains entry into the cytosol its mechanism for attack of the [[Ribosome|ribosome]] is depurination of a single endenosine residue in large RNA of the [[Large Ribosomal Subunit of Haloarcula|large ribosomal subunit]]<ref name="rapak" />, which in humans is called the 28S ribosomal RNA because of its sedimentation properties during ultracentrifugation. Depurination of the ribosomal RNA by the poison in turn results in the inhibition of protein synthesis.
+	The mechanism deployed by Ricin to gain entry to a host cell involves the poison's heterogenic properties. First, the toxin arranges itself in such a way where its B chain can easily interact with the host cells receptors, and once acknowledgement happens, the B chain can facilitate transport of the A chain into the cytoplasm<ref name="montfort" />. This association between the A and B chain is essential for toxicity<ref name="montfort" /> without it the Ricin would not be able to gain access to the cells organelles rendering it useless. Once the A chain gains entry into the cytosol its mechanism for attack of the [[Ribosome|ribosome]] is depurination of a single adenosine residue in a highly conserved portion within the large RNA of the [[Large Ribosomal Subunit of Haloarcula|large ribosomal subunit]]<ref name="rapak" /> of eukaryotes, which in humans is called the 28S ribosomal RNA because of its sedimentation properties during ultracentrifugation. The nucleotide depurinated is located within a loop referred to as the the the <nowiki>'</nowiki>sarcin-ricin loop<nowiki>'</nowiki>, that is important for binding [[elongation factors]] during the course of [[Translation|translation]]. Depurination of the single adenosine nucleotide by the toxin results in the inhibition of protein synthesis.
 ==3D structures of ricin==