1a8a: Difference between revisions

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==Overview==

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.

==About this Structure==

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[[Category: Rattus norvegicus]]

[[Category: Single protein]]

[[Category: Concha, N.O.]]

[[Category: Concha, N O.]]

[[Category: Dedman, J.R.]]

[[Category: Dedman, J R.]]

[[Category: Kaetzel, M.A.]]

[[Category: Kaetzel, M A.]]

[[Category: Seaton, B.A.]]

[[Category: Seaton, B A.]]

[[Category: Swairjo, M.A.]]

[[Category: Swairjo, M A.]]

[[Category: CA]]

[[Category: GSE]]

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[[Category: phospholipid analog]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun~~ Feb ~~3 09~~:29:31 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:00 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as, annexins, protein kinase C, and certain coagulation proteins. Crystal, structures of Ca(2+)-annexin V complexes with phospholipid polar heads, provide molecular details of 'Ca(2+)-bridges' as key features in the, membrane attachment exhibited by these proteins. Distinct binding sites, for phospholipid head groups are observed, including a novel, double-Ca2+, recognition site for phosphoserine that may serve as a phosphatidylserine, receptor site in vivo.
+Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Rattus norvegicus]]
 [[Category: Single protein]]
-[[Category: Concha, N.O.]]
+[[Category: Concha, N O.]]
-[[Category: Dedman, J.R.]]
+[[Category: Dedman, J R.]]
-[[Category: Kaetzel, M.A.]]
+[[Category: Kaetzel, M A.]]
-[[Category: Seaton, B.A.]]
+[[Category: Seaton, B A.]]
-[[Category: Swairjo, M.A.]]
+[[Category: Swairjo, M A.]]
 [[Category: CA]]
 [[Category: GSE]]
@@ Line 24: / Line 24: @@
 [[Category: phospholipid analog]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:29:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:00 2008''