1aet: Difference between revisions
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==Overview== | ==Overview== | ||
Conformational changes that gate the access of substrates or ligands to an | Conformational changes that gate the access of substrates or ligands to an active site are important features of enzyme function. In this report, we describe an unusual example of a structural rearrangement near a buried artificial cavity in cytochrome c peroxidase that occurs on binding protonated benzimidazole. A hinged main-chain rotation at two residues (Pro 190 and Asn 195) results in a surface loop rearrangement that opens a large solvent-accessible channel for the entry of ligands to an otherwise inaccessible binding site. The trapping of this alternate conformational state provides a unique view of the extent to which protein dynamics can allow small molecule penetration into buried protein cavities. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bunte, S | [[Category: Bunte, S W.]] | ||
[[Category: Goodin, D | [[Category: Goodin, D B.]] | ||
[[Category: Jensen, G | [[Category: Jensen, G M.]] | ||
[[Category: Mcree, D | [[Category: Mcree, D E.]] | ||
[[Category: Musah, R | [[Category: Musah, R A.]] | ||
[[Category: Rosenfeld, R.]] | [[Category: Rosenfeld, R.]] | ||
[[Category: 1MZ]] | [[Category: 1MZ]] | ||
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[[Category: transit peptide]] | [[Category: transit peptide]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:43:46 2008'' | ||
