Post-translational modification: Difference between revisions
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*Alkylation, notably methylation, S-prenylation, and adenylation. | *Alkylation, notably methylation, S-prenylation, and adenylation. | ||
*Oxidation, notably creating hydroxylated proline, lysine, asparagine, and glutamic acid, as well as sulfation or [[nitrotyrosine|nitrosylation]] of tyrosine. | *Oxidation, notably creating hydroxylated proline, lysine, asparagine, and glutamic acid, as well as sulfation or [[nitrotyrosine|nitrosylation]] of tyrosine. | ||
*C-terminal amidation, neutralizing the charge. | |||
*Proteolysis | |||
==Consequences for Function== | |||
PTM induce conformational changes in proteins, and affect oligomerization and [[ligand]] binding. PTM may affect catalysis by direct modification of catalytic residues, modification of nearby residues, or effects on regulation. | PTM induce conformational changes in proteins, and affect oligomerization and [[ligand]] binding. PTM may affect catalysis by direct modification of catalytic residues, modification of nearby residues, or effects on regulation. | ||
