1e5d: Difference between revisions
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==Overview== | ==Overview== | ||
Desulfovibrio gigas is a strict anaerobe that contains a | Desulfovibrio gigas is a strict anaerobe that contains a well-characterized metabolic pathway that enables it to survive transient contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct and safe way. The 2.5 A resolution crystal structure of ROO shows that each monomer of this homodimeric enzyme consists of a novel combination of two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain that contains a di-iron center for dioxygen reduction. This is the first structure of a member of a superfamily of enzymes widespread in strict and facultative anaerobes, indicating its broad physiological significance. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Desulfovibrio gigas]] | [[Category: Desulfovibrio gigas]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Carrondo, M | [[Category: Carrondo, M A.]] | ||
[[Category: Coelho, R.]] | [[Category: Coelho, R.]] | ||
[[Category: Frazao, C.]] | [[Category: Frazao, C.]] | ||
[[Category: Gall, J | [[Category: Gall, J Le.]] | ||
[[Category: Gomes, C | [[Category: Gomes, C M.]] | ||
[[Category: Liu, M | [[Category: Liu, M Y.]] | ||
[[Category: Macedo, S.]] | [[Category: Macedo, S.]] | ||
[[Category: Matias, P.]] | [[Category: Matias, P.]] | ||
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[[Category: Silva, G.]] | [[Category: Silva, G.]] | ||
[[Category: Teixeira, M.]] | [[Category: Teixeira, M.]] | ||
[[Category: Xavier, A | [[Category: Xavier, A V.]] | ||
[[Category: FEO]] | [[Category: FEO]] | ||
[[Category: FMN]] | [[Category: FMN]] | ||
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[[Category: oxygenreductase]] | [[Category: oxygenreductase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:24:00 2008'' | ||
Revision as of 10:24, 21 February 2008
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RUBREDOXIN OXYGEN:OXIDOREDUCTASE (ROO) FROM ANAEROBE DESULFOVIBRIO GIGAS
Overview
Desulfovibrio gigas is a strict anaerobe that contains a well-characterized metabolic pathway that enables it to survive transient contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct and safe way. The 2.5 A resolution crystal structure of ROO shows that each monomer of this homodimeric enzyme consists of a novel combination of two domains, a flavodoxin-like domain and a Zn-beta-lactamase-like domain that contains a di-iron center for dioxygen reduction. This is the first structure of a member of a superfamily of enzymes widespread in strict and facultative anaerobes, indicating its broad physiological significance.
About this Structure
1E5D is a Single protein structure of sequence from Desulfovibrio gigas with FMN, FEO and OXY as ligands. Known structural/functional Sites: FEA, FEB, FMA and FMB. Full crystallographic information is available from OCA.
Reference
Structure of a dioxygen reduction enzyme from Desulfovibrio gigas., Frazao C, Silva G, Gomes CM, Matias P, Coelho R, Sieker L, Macedo S, Liu MY, Oliveira S, Teixeira M, Xavier AV, Rodrigues-Pousada C, Carrondo MA, Le Gall J, Nat Struct Biol. 2000 Nov;7(11):1041-5. PMID:11062560
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Desulfovibrio gigas
- Single protein
- Carrondo, M A.
- Coelho, R.
- Frazao, C.
- Gall, J Le.
- Gomes, C M.
- Liu, M Y.
- Macedo, S.
- Matias, P.
- Oliveira, S.
- Rodrigues-Pousada, C.
- Sieker, L.
- Silva, G.
- Teixeira, M.
- Xavier, A V.
- FEO
- FMN
- OXY
- Diiron-centre
- Flavoproteins
- Lactamase-fold
- Oxidoreductase
- Oxygenreductase
