Urokinase: Difference between revisions
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{{ | {{STRUCTURE_1fv9| PDB=1fv9 | SIZE=400| SCENE= |right|CAPTION=Human urokinase A and B chains complex with inhibitor, [[1fv9]] }} | ||
'''Urokinase''' (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage. | '''Urokinase''' (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage. | ||