2wgj: Difference between revisions

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Revision as of 04:56, 28 September 2011

File:2wgj.png

Template:STRUCTURE 2wgj

X-RAY STRUCTURE OF PF-02341066 BOUND TO THE KINASE DOMAIN OF C-MET

Template:ABSTRACT PUBMED 21812414

About this Structure

2wgj is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Cui JJ, Tran-Dube M, Shen H, Nambu M, Kung PP, Pairish M, Jia L, Meng J, Funk L, Botrous I, McTigue M, Grodsky N, Ryan K, Padrique E, Alton G, Timofeevski S, Yamazaki S, Li Q, Zou H, Christensen J, Mroczkowski B, Bender S, Kania RS, Edwards MP. Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK). J Med Chem. 2011 Sep 22;54(18):6342-6363. Epub 2011 Aug 18. PMID:21812414 doi:10.1021/jm2007613

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