1glo: Difference between revisions
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==Overview== | ==Overview== | ||
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain | Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by antigen-presenting cells. Therefore, selective inhibition of this enzyme may be useful in modulating class II restricted T-cell responses in immune-related disorders such as rheumatoid arthritis, multiple sclerosis and extrinsic asthma. The three-dimensional structure at 2.2 A resolution of the active-site Cys25-->Ser mutant presented here in an unliganded state provides further insight useful for the design of selective enzyme inhibitors. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Brzozowski, A | [[Category: Brzozowski, A M.]] | ||
[[Category: Hubbard, R | [[Category: Hubbard, R E.]] | ||
[[Category: Lamers, M | [[Category: Lamers, M B.A C.]] | ||
[[Category: Sturt, S | [[Category: Sturt, S L.]] | ||
[[Category: Turkenburg, J | [[Category: Turkenburg, J P.]] | ||
[[Category: Williams, D | [[Category: Williams, D H.]] | ||
[[Category: Wright, L | [[Category: Wright, L M.]] | ||
[[Category: cathepsin s]] | [[Category: cathepsin s]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
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[[Category: thiol proteas]] | [[Category: thiol proteas]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:51:27 2008'' | ||
Revision as of 10:51, 21 February 2008
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CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S
Overview
Cathepsin S (EC 3.4.22.27), a cysteine proteinase of the papain superfamily, plays a critical role in the generation of a major histocompatibility complex (MHC) class II restricted T-cell response by antigen-presenting cells. Therefore, selective inhibition of this enzyme may be useful in modulating class II restricted T-cell responses in immune-related disorders such as rheumatoid arthritis, multiple sclerosis and extrinsic asthma. The three-dimensional structure at 2.2 A resolution of the active-site Cys25-->Ser mutant presented here in an unliganded state provides further insight useful for the design of selective enzyme inhibitors.
About this Structure
1GLO is a Single protein structure of sequence from Homo sapiens. Active as Cathepsin S, with EC number 3.4.22.27 Known structural/functional Site: CAT. Full crystallographic information is available from OCA.
Reference
Structure of a Cys25-->Ser mutant of human cathepsin S., Turkenburg JP, Lamers MB, Brzozowski AM, Wright LM, Hubbard RE, Sturt SL, Williams DH, Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):451-5. Epub 2002, Feb 21. PMID:11856830
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