1gue: Difference between revisions

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==Overview==

Sensory rhodopsins are the primary receptors of vision in animals and, phototaxis in microorganisms. Light triggers the rapid isomerization of a, buried retinal chromophore, which the protein both accommodates and, amplifies into the larger structural rearrangements required for, signaling. We trapped an early intermediate of the photocycle of sensory, rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and, determined its X-ray structure to 2.3 A resolution. The observed, structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's, beta-ionone ring undergoing a prominent movement. Comparison with the, early structural rearrangements of bacteriorhodopsin illustrates how, modifications in the retinal binding pocket of pSRII allow subtle, differences in the early relaxation of photoisomerized retinal.

Sensory rhodopsins are the primary receptors of vision in animals and phototaxis in microorganisms. Light triggers the rapid isomerization of a buried retinal chromophore, which the protein both accommodates and amplifies into the larger structural rearrangements required for signaling. We trapped an early intermediate of the photocycle of sensory rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and determined its X-ray structure to 2.3 A resolution. The observed structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's beta-ionone ring undergoing a prominent movement. Comparison with the early structural rearrangements of bacteriorhodopsin illustrates how modifications in the retinal binding pocket of pSRII allow subtle differences in the early relaxation of photoisomerized retinal.

==About this Structure==

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[[Category: Single protein]]

[[Category: Edman, K.]]

[[Category: Landau, E.M.]]

[[Category: Landau, E M.]]

[[Category: Maxwell, C.A.]]

[[Category: Maxwell, C A.]]

[[Category: Navarro, J.]]

[[Category: Neutze, R.]]

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[[Category: phototaxis]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:03 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Sensory rhodopsins are the primary receptors of vision in animals and, phototaxis in microorganisms. Light triggers the rapid isomerization of a, buried retinal chromophore, which the protein both accommodates and, amplifies into the larger structural rearrangements required for, signaling. We trapped an early intermediate of the photocycle of sensory, rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and, determined its X-ray structure to 2.3 A resolution. The observed, structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's, beta-ionone ring undergoing a prominent movement. Comparison with the, early structural rearrangements of bacteriorhodopsin illustrates how, modifications in the retinal binding pocket of pSRII allow subtle, differences in the early relaxation of photoisomerized retinal.
+Sensory rhodopsins are the primary receptors of vision in animals and phototaxis in microorganisms. Light triggers the rapid isomerization of a buried retinal chromophore, which the protein both accommodates and amplifies into the larger structural rearrangements required for signaling. We trapped an early intermediate of the photocycle of sensory rhodopsin II from Natronobacterium pharaonis (pSRII) in 3D crystals and determined its X-ray structure to 2.3 A resolution. The observed structural rearrangements were localized near the retinal chromophore, with a key water molecule becoming disordered and the retinal's beta-ionone ring undergoing a prominent movement. Comparison with the early structural rearrangements of bacteriorhodopsin illustrates how modifications in the retinal binding pocket of pSRII allow subtle differences in the early relaxation of photoisomerized retinal.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Edman, K.]]
-[[Category: Landau, E.M.]]
+[[Category: Landau, E M.]]
-[[Category: Maxwell, C.A.]]
+[[Category: Maxwell, C A.]]
 [[Category: Navarro, J.]]
 [[Category: Neutze, R.]]
@@ Line 27: / Line 27: @@
 [[Category: phototaxis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:42:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:54:03 2008''