1h00: Difference between revisions
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==Overview== | ==Overview== | ||
Using a high-throughput screening campaign, we identified the 4,6-bis | Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Transferred entry: 2 | [[Category: Transferred entry: 2 7.11 1]] | ||
[[Category: Beattie, J | [[Category: Beattie, J F.]] | ||
[[Category: Breault, G | [[Category: Breault, G A.]] | ||
[[Category: Ellston, R | [[Category: Ellston, R P.A.]] | ||
[[Category: Green, S.]] | [[Category: Green, S.]] | ||
[[Category: Jewsbury, P | [[Category: Jewsbury, P J.]] | ||
[[Category: Midgley, C | [[Category: Midgley, C J.]] | ||
[[Category: Minshull, C | [[Category: Minshull, C A.]] | ||
[[Category: Naven, R | [[Category: Naven, R T.]] | ||
[[Category: Pauptit, R | [[Category: Pauptit, R A.]] | ||
[[Category: Pease, J | [[Category: Pease, J E.]] | ||
[[Category: Tucker, J | [[Category: Tucker, J A.]] | ||
[[Category: ACE]] | [[Category: ACE]] | ||
[[Category: FAP]] | [[Category: FAP]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:55:53 2008'' | ||
