3ojy: Difference between revisions

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~~[[Image:3ojy.png|left|200px]]~~

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===Crystal Structure of Human Complement Component C8===

==Disease==

[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.

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==Function==

~~The line below this paragraph, {{ABSTRACT_PUBMED_21454577}}, adds~~ the ~~Publication Abstract to~~ the ~~page~~

[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref><ref>PMID:17872444</ref> [[http://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 21454577~~ is the ~~PubMed ID number~~.

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~~{{ABSTRACT_PUBMED_21454577}}~~

==About this Structure==

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==Reference==

[[Category: Homo sapiens]]

[[Category: Cooper, C L.]]

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@@ Line 1: / Line 1: @@
-[[Image:3ojy.png|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3ojy", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3ojy|  PDB=3ojy  |  SCENE=  }}
 ===Crystal Structure of Human Complement Component C8===
+{{ABSTRACT_PUBMED_21454577}}
+==Disease==
+[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[http://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
-<!--
+==Function==
-The line below this paragraph, {{ABSTRACT_PUBMED_21454577}}, adds the Publication Abstract to the page
+[[http://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref><ref>PMID:17872444</ref> [[http://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
-(as it appears on PubMed at http://www.pubmed.gov), where 21454577 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21454577}}
 ==About this Structure==
@@ Line 22: / Line 13: @@
 ==Reference==
-<ref group="xtra">PMID:021454577</ref><references group="xtra"/>
+<ref group="xtra">PMID:021454577</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Cooper, C L.]]