1het: Difference between revisions

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==Overview==

Atomic (1 A) resolution x-ray structures of horse liver alcohol, dehydrogenase in complex with NADH revealed the formation of an adduct in, the active site between a metal-bound water and NADH. Furthermore, a, pronounced distortion of the pyridine ring of NADH was observed. A series, of quantum chemical calculations on the water-nicotinamide adduct showed, that the puckering of the pyridine ring in the crystal structures can only, be reproduced when the water is considered a hydroxide ion. These, observations provide fundamental insight into the enzymatic activation of, NADH for hydride transfer.

Atomic (1 A) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the crystal structures can only be reproduced when the water is considered a hydroxide ion. These observations provide fundamental insight into the enzymatic activation of NADH for hydride transfer.

==About this Structure==

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[[Category: Equus caballus]]

[[Category: Single protein]]

[[Category: Adolph, H.W.]]

[[Category: Adolph, H W.]]

[[Category: Cedergen-Zeppezauer, E.S.]]

[[Category: Cedergen-Zeppezauer, E S.]]

[[Category: Lamzin, V.S.]]

[[Category: Lamzin, V S.]]

[[Category: Meijers, R.]]

[[Category: Merli, A.]]

[[Category: Morris, R.J.]]

[[Category: Morris, R J.]]

[[Category: MRD]]

[[Category: NAD]]

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[[Category: oxidoreductase(nad(a)-choh(d))]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:32 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Atomic (1 A) resolution x-ray structures of horse liver alcohol, dehydrogenase in complex with NADH revealed the formation of an adduct in, the active site between a metal-bound water and NADH. Furthermore, a, pronounced distortion of the pyridine ring of NADH was observed. A series, of quantum chemical calculations on the water-nicotinamide adduct showed, that the puckering of the pyridine ring in the crystal structures can only, be reproduced when the water is considered a hydroxide ion. These, observations provide fundamental insight into the enzymatic activation of, NADH for hydride transfer.
+Atomic (1 A) resolution x-ray structures of horse liver alcohol dehydrogenase in complex with NADH revealed the formation of an adduct in the active site between a metal-bound water and NADH. Furthermore, a pronounced distortion of the pyridine ring of NADH was observed. A series of quantum chemical calculations on the water-nicotinamide adduct showed that the puckering of the pyridine ring in the crystal structures can only be reproduced when the water is considered a hydroxide ion. These observations provide fundamental insight into the enzymatic activation of NADH for hydride transfer.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Equus caballus]]
 [[Category: Single protein]]
-[[Category: Adolph, H.W.]]
+[[Category: Adolph, H W.]]
-[[Category: Cedergen-Zeppezauer, E.S.]]
+[[Category: Cedergen-Zeppezauer, E S.]]
-[[Category: Lamzin, V.S.]]
+[[Category: Lamzin, V S.]]
 [[Category: Meijers, R.]]
 [[Category: Merli, A.]]
-[[Category: Morris, R.J.]]
+[[Category: Morris, R J.]]
 [[Category: MRD]]
 [[Category: NAD]]
@@ Line 25: / Line 25: @@
 [[Category: oxidoreductase(nad(a)-choh(d))]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:48:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:00:32 2008''