3u0z: Difference between revisions

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[[Image:3u0z.png|left|200px]]
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{{STRUCTURE_3u0z|  PDB=3u0z  |  SCENE=  }}  
{{STRUCTURE_3u0z|  PDB=3u0z  |  SCENE=  }}  
===Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels===
===Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels===
{{ABSTRACT_PUBMED_22006928}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/HCN1_MOUSE HCN1_MOUSE]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli.<ref>PMID:9630217</ref> <ref>PMID:11675786</ref>
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{{ABSTRACT_PUBMED_22006928}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:022006928</ref><references group="xtra"/>
<ref group="xtra">PMID:022006928</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Arrigoni, C.]]
[[Category: Arrigoni, C.]]

Revision as of 14:27, 10 July 2013

Template:STRUCTURE 3u0z

Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels

Template:ABSTRACT PUBMED 22006928

Function

[HCN1_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli.[1] [2]

About this Structure

3u0z is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. Lolicato M, Nardini M, Gazzarrini S, Moeller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A. Tetramerization dynamics of the C-terminal domain underlies isoform-specific cAMP-gating in Hyperpolarization-activated Cyclic Nucleotide gated channels. J Biol Chem. 2011 Oct 17. PMID:22006928 doi:10.1074/jbc.M111.297606
  1. ↑ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29. PMID:9630217
  2. ↑ Stevens DR, Seifert R, Bufe B, Muller F, Kremmer E, Gauss R, Meyerhof W, Kaupp UB, Lindemann B. Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature. 2001 Oct 11;413(6856):631-5. PMID:11675786 doi:10.1038/35098087

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