2l6k: Difference between revisions

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[[Image:2l6k.png|left|200px]]
==Solution Structure of a Nonphosphorylated Peptide Recognizing Domain==
<StructureSection load='2l6k' size='340' side='right' caption='[[2l6k]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
[[2l6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6K OCA]. <br>
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
== Publication Abstract from PubMed ==
BACKGROUND: Src homology 2 (SH2) domain is a conserved module involved in various biological processes. Tensin family member was reported to be involved in tumor suppression by interacting with DLC-1 (deleted-in-liver-cancer-1) via its SH2 domain. We explore here the important questions that what the structure of tensin2 SH2 domain is, and how it binds to DLC-1, which might reveal a novel binding mode. PRINCIPAL FINDINGS: Tensin2 SH2 domain adopts a conserved SH2 fold that mainly consists of five beta-strands flanked by two alpha-helices. Most SH2 domains recognize phosphorylated ligands specifically. However, tensin2 SH2 domain was identified to interact with nonphosphorylated ligand (DLC-1) as well as phosphorylated ligand. CONCLUSIONS: We determined the solution structure of tensin2 SH2 domain using NMR spectroscopy, and revealed the interactions between tensin2 SH2 domain and its ligands in a phosphotyrosine-independent manner.


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Solution structure of Tensin2 SH2 domain and its phosphotyrosine-independent interaction with DLC-1.,Dai K, Liao S, Zhang J, Zhang X, Tu X PLoS One. 2011;6(7):e21965. Epub 2011 Jul 12. PMID:21765928<ref>PMID:21765928</ref>
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{{STRUCTURE_2l6k|  PDB=2l6k  |  SCENE=  }}


===Solution Structure of a Nonphosphorylated Peptide Recognizing Domain===
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
 
== References ==
 
<references/>
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{{ABSTRACT_PUBMED_21765928}}
 
==About this Structure==
[[2l6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6K OCA].
 
==Reference==
<ref group="xtra">PMID:021765928</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Dai, K.]]
[[Category: Dai, K.]]
Retrieved from "https://proteopedia.org/2l6k"