1nox: Difference between revisions

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==Overview==

The crystal structures of the flavin adenine dinucleotide (FAD) and flavin, mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus, thermophilus have been determined by isomorphous and molecular replacement, and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6%, respectively. The structure of the homodimeric enzyme consists of a, central 4-stranded antiparallel beta-sheet covered by helices, a more, flexible domain formed by two helices, and a C-terminal excursion, connecting the subunits. The active sites are located in a deep cleft, between the subunits. The binding site of the flavin cofactor lacks the, common nucleotide binding fold and is different from the FMN binding site, found in flavodoxins.

The crystal structures of the flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus thermophilus have been determined by isomorphous and molecular replacement and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6% respectively. The structure of the homodimeric enzyme consists of a central 4-stranded antiparallel beta-sheet covered by helices, a more flexible domain formed by two helices, and a C-terminal excursion connecting the subunits. The active sites are located in a deep cleft between the subunits. The binding site of the flavin cofactor lacks the common nucleotide binding fold and is different from the FMN binding site found in flavodoxins.

==About this Structure==

Line 15:

[[Category: Thermus thermophilus]]

[[Category: Erdmann, H.]]

[[Category: Hecht, H.J.]]

[[Category: Hecht, H J.]]

[[Category: Park, H.J.]]

[[Category: Park, H J.]]

[[Category: Schmid, R.D.]]

[[Category: Schmid, R D.]]

[[Category: Sprinzl, M.]]

[[Category: FMN]]

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[[Category: thermophile]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structures of the flavin adenine dinucleotide (FAD) and flavin, mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus, thermophilus have been determined by isomorphous and molecular replacement, and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6%, respectively. The structure of the homodimeric enzyme consists of a, central 4-stranded antiparallel beta-sheet covered by helices, a more, flexible domain formed by two helices, and a C-terminal excursion, connecting the subunits. The active sites are located in a deep cleft, between the subunits. The binding site of the flavin cofactor lacks the, common nucleotide binding fold and is different from the FMN binding site, found in flavodoxins.
+The crystal structures of the flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus thermophilus have been determined by isomorphous and molecular replacement and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6% respectively. The structure of the homodimeric enzyme consists of a central 4-stranded antiparallel beta-sheet covered by helices, a more flexible domain formed by two helices, and a C-terminal excursion connecting the subunits. The active sites are located in a deep cleft between the subunits. The binding site of the flavin cofactor lacks the common nucleotide binding fold and is different from the FMN binding site found in flavodoxins.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Thermus thermophilus]]
 [[Category: Erdmann, H.]]
-[[Category: Hecht, H.J.]]
+[[Category: Hecht, H J.]]
-[[Category: Park, H.J.]]
+[[Category: Park, H J.]]
-[[Category: Schmid, R.D.]]
+[[Category: Schmid, R D.]]
 [[Category: Sprinzl, M.]]
 [[Category: FMN]]
@@ Line 25: / Line 25: @@
 [[Category: thermophile]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:54:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:08:24 2008''