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==Overview== | ==Overview== | ||
Sialoadhesin is a sialic acid-binding immunoglobulin-like lectin (Siglec), expressed on subsets of macrophages. It is a model system for Siglec | Sialoadhesin is a sialic acid-binding immunoglobulin-like lectin (Siglec), expressed on subsets of macrophages. It is a model system for Siglec receptor-mediated cell surface interactions through binding of sialylated glycoconjugates. The N-terminal sialoadhesin domain can mediate sialic acid-binding on its own. The structure of this domain has been determined in complex with a sialic acid-containing heptapeptide, (Ala-Gly-His-Thr(Neu5Ac)-Trp-Gly-His). The affinity of sialoadhesin for this ligand is four times higher than the affinity for the natural linkage 2,3'-sialyllactose. The structure of the glycopeptide complex suggests strategies for ligand optimization and provides possible explanations for the observed differences in specificities among the Siglecs. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bukrinsky, J | [[Category: Bukrinsky, J T.]] | ||
[[Category: Crocker, P | [[Category: Crocker, P R.]] | ||
[[Category: Henriksen, A.]] | [[Category: Henriksen, A.]] | ||
[[Category: Hilaire, P | [[Category: Hilaire, P M.S.]] | ||
[[Category: Meldal, M.]] | [[Category: Meldal, M.]] | ||
[[Category: SIA]] | [[Category: SIA]] | ||
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[[Category: sialoadhesin]] | [[Category: sialoadhesin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:27:29 2008'' | ||
