1uup: Difference between revisions

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==Overview==

Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen, associated with scarlet fever and streptococcal toxic shock syndrome, (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous, work suggested that the dimer results from an intermolecular disulfide, bond between the cysteines at positions 90 of each monomer. Here, we, present the crystal structure of the dimeric form of SpeA1. The toxin, crystallizes in the orthorhombic space group P212121, with two dimers in, the crystallographic asymmetric unit. The final structure has a, crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water, molecules, and 4 zinc atoms (one zinc atom per molecule). The implications, of SpeA1 dimer on MHC class II and T-cell receptor recognition are, discussed.

Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen associated with scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous work suggested that the dimer results from an intermolecular disulfide bond between the cysteines at positions 90 of each monomer. Here, we present the crystal structure of the dimeric form of SpeA1. The toxin crystallizes in the orthorhombic space group P212121, with two dimers in the crystallographic asymmetric unit. The final structure has a crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water molecules, and 4 zinc atoms (one zinc atom per molecule). The implications of SpeA1 dimer on MHC class II and T-cell receptor recognition are discussed.

==About this Structure==

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[[Category: Single protein]]

[[Category: Streptococcus pyogenes]]

[[Category: Acharya, K.R.]]

[[Category: Acharya, K R.]]

[[Category: Baker, M.D.]]

[[Category: Baker, M D.]]

[[Category: Collins, C.M.]]

[[Category: Collins, C M.]]

[[Category: Gendlina, I.]]

[[Category: ZN]]

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[[Category: zinc binding]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen, associated with scarlet fever and streptococcal toxic shock syndrome, (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous, work suggested that the dimer results from an intermolecular disulfide, bond between the cysteines at positions 90 of each monomer. Here, we, present the crystal structure of the dimeric form of SpeA1. The toxin, crystallizes in the orthorhombic space group P212121, with two dimers in, the crystallographic asymmetric unit. The final structure has a, crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water, molecules, and 4 zinc atoms (one zinc atom per molecule). The implications, of SpeA1 dimer on MHC class II and T-cell receptor recognition are, discussed.
+Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen associated with scarlet fever and streptococcal toxic shock syndrome (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous work suggested that the dimer results from an intermolecular disulfide bond between the cysteines at positions 90 of each monomer. Here, we present the crystal structure of the dimeric form of SpeA1. The toxin crystallizes in the orthorhombic space group P212121, with two dimers in the crystallographic asymmetric unit. The final structure has a crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water molecules, and 4 zinc atoms (one zinc atom per molecule). The implications of SpeA1 dimer on MHC class II and T-cell receptor recognition are discussed.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Single protein]]
 [[Category: Streptococcus pyogenes]]
-[[Category: Acharya, K.R.]]
+[[Category: Acharya, K R.]]
-[[Category: Baker, M.D.]]
+[[Category: Baker, M D.]]
-[[Category: Collins, C.M.]]
+[[Category: Collins, C M.]]
 [[Category: Gendlina, I.]]
 [[Category: ZN]]
@@ Line 26: / Line 26: @@
 [[Category: zinc binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:08:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:28:36 2008''