Sandbox 37: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[Image:Papaya.jpg | right| thumb| ''Carica papaya'']] | [[Image:Papaya.jpg | right| thumb| ''Carica papaya'']] | ||
<scene name='Sandbox_37/Main_scene/1'>Papain</scene> is a cysteine protease that is stable and active under a wide range of conditions. The enzyme present in the leaves, latex, roots, and fruit of the papaya plant(''Carica papaya''). | <scene name='Sandbox_37/Main_scene/1'>Papain</scene> is a cysteine protease that is stable and active under a wide range of conditions. The enzyme present in the leaves, latex, roots, and fruit of the papaya plant (''Carica papaya'').<ref>http://www.britannica.com/EBchecked/topic/441803/papain</ref> The papain proteins are synthesized as inactive precursors that become active within two minutes of the plant being wounded and the latex is expelled.<ref>http://www.worthington-biochem.com/pap/default.html</ref> | ||
==Structure== | ==Structure== | ||
<StructureSection load='9PAP' size='400' align='left' caption='Papain (9PAP)' scene=''></StructureSection> | <StructureSection load='9PAP' size='400' align='left' caption='Papain (9PAP)' scene=''></StructureSection> Papain consists of one polypepetide chain that is made up of 212 amino acids residues. There are three <scene name='Sandbox_37/Papain_disulfide_bonds/1'>disulfide bonds</scene> present in the enzyme that maintains the protein's structure. | ||
<scene name='Sandbox_37/Papain_beta-alpha/1'>secondary structure</scene> | <scene name='Sandbox_37/Papain_beta-alpha/1'>secondary structure</scene> | ||
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<scene name='Sandbox_37/Papain_hydrogen_bonds/1'>hydrogen bonds</scene> | <scene name='Sandbox_37/Papain_hydrogen_bonds/1'>hydrogen bonds</scene> | ||
==Mechanism== | ==Mechanism== | ||
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<ref>http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=1POP¶ms.chainEntityStrategyStr=all</ref> | <ref>http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=1POP¶ms.chainEntityStrategyStr=all</ref> | ||
<ref>http://en.wikipedia.org/wiki/Papain</ref> | <ref>http://en.wikipedia.org/wiki/Papain</ref> | ||
<ref>http://www.pdb.org/pdb/explore.do?structureId=9PAP</ref> | <ref>http://www.pdb.org/pdb/explore.do?structureId=9PAP</ref> | ||
<ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> | <ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> | ||
==References== | ==References== | ||
<references /> | <references /> | ||
