Sandbox 34: Difference between revisions

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[[Image:Papainmech6.jpg|200px|left|thumb| General mechanism of papain catalysis<ref>[http://chemistry.umeche.maine.edu/CHY431/Peptidase10.html] University of Maine</ref>.]]
 
== Papain ==
== Papain ==


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== Catalytic Mechanism ==
== Catalytic Mechanism ==


[[Image:PapainMechanism.gif|200px|left|thumb]]
[[Image:Papainmech6.jpg|200px|left|thumb| General mechanism of papain catalysis<ref>[http://chemistry.umeche.maine.edu/CHY431/Peptidase10.html] University of Maine</ref>.]]  


== Inhibitors ==
== Inhibitors ==


There are many inhibitors for papain because of its broad specificity.  
There are many inhibitors for papain because of its broad specificity. The inhibition of papain is usually due to active site restriction. An interesting inhibitor is that of <scene name='Sandbox_34/Clik148_inhibitor/1'>Clik148</scene>. This inhibitor uses both prime and non-prime sites to inhibit papain.<ref> PMID:10600517 </ref>  
<scene name='Sandbox_34/Clik148_inhibitor/1'>Clik148</scene><ref> PMID:10600517 </ref>
 


== References ==
== References ==