Sandbox 43: Difference between revisions
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== '''C11 Alkyl | == '''C11 Alkyl Phosphonate Inhibitor''' == | ||
Lipase inhibitors are of medical importance because they can be used to block the absorption of fats by the body, aiding in weight loss. One such inhibitor is C11 | Lipase inhibitors are of medical importance because they can be used to block the absorption of fats by the body, aiding in weight loss. One such inhibitor is C11 alkyl phosphonate which <scene name='Sandbox_43/C11_inhibition/1'>interacts with lipase</scene> and inhibits its active site. This inhibitor forms a covalent bond with Ser-152 as well as forming hydrophobic interactions with the ampipathic lipase lid and mimicking the the interactions between the leaving fatty acid of triglyceride and lipase. Combined these successfully destroy the functionality of the active site while C11 is still bound. | ||
