Sandbox 43: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 16: | Line 16: | ||
== '''Colipase Cofactor''' == | == '''Colipase Cofactor''' == | ||
<scene name='Sandbox_43/Colipase/1'>Colipase</scene> is a small protein that is necessary for efficient lipid catalysis by lipase. It is secreted by the pancreas in its inactive form as procolipase which is converted into the active colipase by trypsin. It binds to the non-catalytic C-terminal domain of lipase and in so doing stabilizes its active conformation as it hydrolyzes lipids. Furthermore, it also binds to the lipid interface, increasing the affinity between lipase and the lipid. | <scene name='Sandbox_43/Colipase/1'>Colipase</scene> is a small protein that is necessary for efficient lipid catalysis by lipase. It is secreted by the pancreas in its inactive form as procolipase which is converted into the active colipase by trypsin. It binds to the non-catalytic C-terminal domain of lipase and in so doing stabilizes its active conformation as it hydrolyzes lipids. Furthermore, it also binds to the lipid interface, increasing the affinity between lipase and the lipid.<ref>http://en.wikipedia.org/wiki/Colipase</ref> | ||
== '''Mechanism of Triglyceride Hydrolysis''' == | == '''Mechanism of Triglyceride Hydrolysis''' == | ||
