Sandbox 31: Difference between revisions
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==Inhibitors== | ==Inhibitors==sd | ||
There are many inhibitors of cysteine proteases like papain | There are many inhibitors of cysteine proteases like papain including antipain, cystatin, Hg2+, and Leupeptin. Leupeptin is a commonly studied inhibitor of proteases. It inhibits by binding and interacting with the active site which allows it to block the enzyme's desired protein substrate. There are many <scene name='Sandbox_31/1popligand_contacts/1'>Residues</scene> that interact with Leupeptin in the active site. The predominant interaction is from hydrophobic interactions between Leupeptin and <scene name='Sandbox_31/1pophydrointeract/1'>active site residues</scene>. | ||
<scene name='Sandbox_31/ | |||
<scene name='Sandbox_31/1pophydrointeract/1'>Hydrophobic Interactions</scene> | |||
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http://peds.oxfordjournals.org/content/7/1/75.abstract | http://peds.oxfordjournals.org/content/7/1/75.abstract | ||
http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=9PAP | http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=9PAP | ||
http://faculty.csusm.edu/lcohen/index.html | |||
