Sandbox 34: Difference between revisions

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== Structure ==

Papain is a relatively simple enzyme. It consists of only one chain of 212 residues with three disulfide bonds, illustrated in yellow.<ref name="Structure" /> A modified cysteine residue with a sulfhydryl group, <scene name='Sandbox_34/9pap_sulfhydryl_group/1'>cysteine sulfonic acid</scene>, is necessary for the activity of the enzyme.<ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> In 9PAP, the sulfhydryl group has been oxidized. Papain contains many <scene name='Sandbox_34/~~Papain_hydrophobic_regions~~/1'>hydrophobic regions</scene> illustrated in magenta.

Papain is a relatively simple enzyme. It consists of only one chain of 212 residues with three disulfide bonds, illustrated in yellow.<ref name="Structure" /> The single chain is separated into two domains that form a cleft in which the active site resides.<ref name="PDBSum" /> A modified cysteine residue with a sulfhydryl group, <scene name='Sandbox_34/9pap_sulfhydryl_group/1'>cysteine sulfonic acid</scene>, is necessary for the activity of the enzyme.<ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> In 9PAP, the sulfhydryl group has been oxidized. Papain contains many <scene name='Sandbox_34/Pap_hydrophobic_polar/1'>hydrophobic regions</scene>, illustrated in grey, in addition to many polar regions, illustrated in magenta. It is easy to see that the <scene name='Sandbox_34/Pap_hydrophobic_focus/1'>hydrophobic regions</scene> tend towards the interior of the molecule, while the <scene name='Sandbox_34/Pap_polar_focus/1'>polar residues</scene> tend towards the exterior of the molecule.

=== Ligands ===

Sandbox 34: Difference between revisions

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 == Structure ==
-Papain is a relatively simple enzyme. It consists of only one chain of 212 residues with three disulfide bonds, illustrated in yellow.<ref name="Structure" /> A modified cysteine residue with a sulfhydryl group, <scene name='Sandbox_34/9pap_sulfhydryl_group/1'>cysteine sulfonic acid</scene>, is necessary for the activity of the enzyme.<ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> In 9PAP, the sulfhydryl group has been oxidized. Papain contains many <scene name='Sandbox_34/Papain_hydrophobic_regions/1'>hydrophobic regions</scene> illustrated in magenta.
+Papain is a relatively simple enzyme. It consists of only one chain of 212 residues with three disulfide bonds, illustrated in yellow.<ref name="Structure" /> The single chain is separated into two domains that form a cleft in which the active site resides.<ref name="PDBSum" /> A modified cysteine residue with a sulfhydryl group, <scene name='Sandbox_34/9pap_sulfhydryl_group/1'>cysteine sulfonic acid</scene>, is necessary for the activity of the enzyme.<ref>http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/papain.html</ref> In 9PAP, the sulfhydryl group has been oxidized. Papain contains many <scene name='Sandbox_34/Pap_hydrophobic_polar/1'>hydrophobic regions</scene>, illustrated in grey, in addition to many polar regions, illustrated in magenta. It is easy to see that the <scene name='Sandbox_34/Pap_hydrophobic_focus/1'>hydrophobic regions</scene> tend towards the interior of the molecule, while the <scene name='Sandbox_34/Pap_polar_focus/1'>polar residues</scene> tend towards the exterior of the molecule.
 === Ligands ===