1ud0: Difference between revisions
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{{STRUCTURE_1ud0| PDB=1ud0 | SCENE= }} | {{STRUCTURE_1ud0| PDB=1ud0 | SCENE= }} | ||
===CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70=== | ===CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70=== | ||
{{ABSTRACT_PUBMED_12773536}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HSP7C_RAT HSP7C_RAT]] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity). | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012773536</ref><references group="xtra"/> | <ref group="xtra">PMID:012773536</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Chou, C C.]] | [[Category: Chou, C C.]] | ||
Revision as of 08:13, 23 April 2014
CRYSTAL STRUCTURE OF THE C-TERMINAL 10-kDA SUBDOMAIN OF HSC70
Template:ABSTRACT PUBMED 12773536
Function
[HSP7C_RAT] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
About this Structure
1ud0 is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Chou CC, Forouhar F, Yeh YH, Shr HL, Wang C, Hsiao CD. Crystal structure of the C-terminal 10-kDa subdomain of Hsc70. J Biol Chem. 2003 Aug 8;278(32):30311-6. Epub 2003 May 28. PMID:12773536 doi:10.1074/jbc.M304563200